JFL : Jurnal Farmasi Lampung https://jurnal.utb.ac.id/index.php/jfl <p><strong>JFL : Jurnal Farmasi Lampung</strong> merupakan media publikasi berupa jurnal ilmiah mengenai ilmu farmasi yang dikelola oleh Program Studi Farmasi Fakultas MIPA Universitas Tulang Bawang. Terbit setiap bulan Juni dan Desember setiap tahun, dengan menerbitkan artikel sebanyak 10 artikel per volumenya. </p> <p><strong> JFL : Jurnal Farmasi Lampung</strong> menerima artikel orisinal tentang hasil-hasil penelitian laboratorium, studi kasus, dan <em>review</em> artikel yang erat kaitannya dengan bidang kefarmasian. Naskah yang dimuat merupakan hasil seleksi dan disetujui oleh Dewan Redaksi dan belum pernah dimuat di jurnal lain.</p> <div id="peerReviewProcess"> <h3><span style="font-size: 14px;">p-ISSN : </span><a href="https://issn.brin.go.id/terbit/detail/1389356930" target="_blank" rel="noopener"><em style="font-size: 14px;"><strong>2355-2506 </strong></em></a><span style="font-size: 14px;">| e-ISSN : </span><em style="font-size: 14px;"><strong><a href="https://issn.brin.go.id/terbit/detail/1505102173" target="_blank" rel="noopener">2598-4896</a></strong></em></h3> </div> Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang en-US JFL : Jurnal Farmasi Lampung 2355-2506 Faktor Yang Berhubungan Dengan Kepatuhan Minum Obat Pada Penderita Skizofrenia Fase Stabil Di Poli Rawat Jalan RS Jiwa Daerah Provinsi Lampung Tahun 2022 https://jurnal.utb.ac.id/index.php/jfl/article/view/1110 <p><em>Adherence with antipsychotic treatment is very important to achieve optimal therapeutic results to the people with schizophrenia. The aim of the study is to determine the factors associated with medication adherence in patients with stable phase of paranoid schizophrenia at the Outpatient Polyclinic of the Regional Hospital of Lampung Province in 2022. This study used a crosssectional method with prospective data collection, a sample of 176 and the use of purposive sampling for the sampling technique. The data obtained were analyzed by using the chi square test to find out the relation between the dependent variable which is medication adherence, and the independent variables, namely perceptions of family support, knowledge related to disease, perceptions of drug side effects, and the perceptions of the pharmacist's role. To find out the dominant factors influencing the medicine compliance, the data were analyzed by using ordinal logistic regression. The study obtained of medicine compliance rates in paranoid schizophrenia patients based on the MMAS scale were good in 53 (30.1%), moderate in 62 (35.2%) and poor in 61 (34.7%). There is a relationship between medication adherence and the perception of family support (p value 0.038), knowledge related to disease (p value 0.005), perception of drug side effects (p value 0.003), and perception of the role of pharmacist (p value 0.000). The dominant factor affecting compliance to taking medication is the perception of the pharmacist's role with OR = 2.8, which means patients who get a good pharmacist role are more compliant in taking medication by 2.8 times. </em></p> <p><em>&nbsp;</em><em>Keywords: Medication Compliance, Paranoid Schizophrenia, Stable Phase, Outpatient</em></p> Nola Harissa Yusi Anggriani Prih Sarnianto Tendry Septa Copyright (c) 2023 https://creativecommons.org/licenses/by-sa/4.0/ 2023-12-02 2023-12-02 12 2 48 54 10.37090/jfl.v12i2.1110 Analisis Tingkat Kepatuhan Dan Keberhasilan Terapi Antiretroviral Pada Pasien Hiv/Aids Di Puskesmas Kota Bandar Lampung Tahun 2022 https://jurnal.utb.ac.id/index.php/jfl/article/view/1246 <p>HIV/AIDS is one of the hazardous infectious diseases that can cause death. To this day, combination antiretroviral treatment (ARV) is the best therapy for patients infected with Human Immunodeficiency Virus (HIV). To determine the success of antiretroviral treatment, monitoring of therapy can be done by doing viral load test. The study purposes were to determine the relationship between the level of compliance and the success of antiretroviral therapy in HIV/AIDS patients at the Bandar Lampung City Health Center in 2022. The method used in this study was a quantitative method using a non-experimental design with a cross-sectional method. The results of the study showed that compliance to taking medication based on the MMAS scale with 37 complied patients (56,1%), 29 patients (43,9%) did not comply, patients with good knowledge were 36 (54,5%), and patients who had less knowledge were 30 (45,5%). HIV/AIDS patients who received support from their families were 34 (51,5%), and quite a lot of patients who did not receive family support, they were 32 patients (48,5%). HIV/AIDS patients who had no side effects from the drugs they were taking were 9 patients (13,6%), and patients who had side effects from the drugs they were taking were 57 patients (86,4%). Patients with undetectable viral load were 18 patients (27.3%), patients with &lt;40 copies/ml were 34 (51,5%), and patients with &gt;40 copies/ml (21,2%) were 14. In addition, there is a relationship between knowledge related to disease, family support, and drug side effects with medication compliance in HIV AIDS patients at the Bandar Lampung Health Center in 2022. There is a relationship between knowledge about the disease, family support, drug side effects, and compliance. Then, there is a relationship between patients’ compliance and the success of ARV drug therapy in HIV/AIDS patients.</p> <p>&nbsp;</p> <p><strong><em>&nbsp; Keywords:</em></strong> medication complication, ARV, HIV/AIDS, <em>viral load</em></p> Kartika Handayani Kartika Wawaimuli Arozal Yati Sumiati Copyright (c) 2023 https://creativecommons.org/licenses/by/4.0/ 2023-12-02 2023-12-02 12 2 55 66 10.37090/jfl.v12i2.1246 Formulasi Dan Uji Aktivitas Sediaan Krim Fraksi Etanol Bunga Pepaya (Carica Papaya L.) Terhadap Bakteri Staphylococcus Aureus Penyebab Jerawat https://jurnal.utb.ac.id/index.php/jfl/article/view/1248 <p><em>Papaya flowers in the community are believed to be antidiabetics, prevent cancer, lower cholesterol, and as antibacterial. Based on its antibacterial properties, the ethanol fraction of papaya flowers will be made in the form of cream preparations. This study aims to find out the activity of papaya flower ethanol fraction cream preparations against the bland growth power of acne-causing Staphylococcus aureus bacteria. </em><em>E</em><em>thanol fractions</em><em> of</em> <em>p</em><em>apaya flower are formulated into cream preparations with fraction concentrations of F1 (2%), F2 (4%), F3 (6%), and F4 (8%) using oil phases (stearic acid, paraffin liquidum, and adeps lanae), water phase (TEA and aquadest) and preservatives (methyl parabens). Furthermore, the cream tested antibacterial activity and physical properties include homogeneity, organoleptic, pH, viscosity, scattering power, adocity and stability.</em> <em>The results showed F1, F2, F3, and F4 each had antibacterial activity against Staphylococcus aureus bacteria as evidenced by the presence of bland zones in F1 (17.35 mm), F2 (17.77 mm), F3 (18.90 mm), and F4 (19.73 mm). The resulting data is normal and homogeneous distributed data so that the results of the ANOVA test show a significant difference of 0.0000 (p ≤ 0.05) and </em><em>T</em><em>ukey Post Hoc test results are obtained significant differences between formulas.</em> <em>The results of the evaluation of cream preparations on observation of homogeneity are less stable and organoleptic have stable results, pH values of 5.62-6.62, viscosity of 4122-4432 cps, scatter power of 5.13-5.70 cm, and akat for 4.86-6.43 seconds. Cycling tests showed stable results in F1, F2 and F3 and less stable in F4. The conclusion of this </em><em>research</em><em> is that the formulation</em> <em>ethanol fraction of papaya flower</em> <em>cream preparations has activity against the inhibition of the growth of acne-causing Staphylococcus aureus bacteria.</em></p> <p><em>&nbsp;</em><strong><em>Keywords:</em></strong><em> Acne, Antibacterial, Carica papaya, Cream, Fraction, Papaya Flower</em></p> Subur Widodo Akhmad Rokiban Laila Susanti Deski Riyanti Copyright (c) 2023 https://creativecommons.org/licenses/by/4.0/ 2023-12-02 2023-12-02 12 2 67 81 10.37090/jfl.v12i2.1248 Antibakteri Fraksi Kloroform Bawang Putih Tunggal (Allium Sativum L.) Terhadap Staphylococcus Aureus Dan Escherichia Coli Serta Penentuan Senyawa Aktifnya Dengan Gc-Ms https://jurnal.utb.ac.id/index.php/jfl/article/view/970 <p><em>Single garlic is one plant that has antibacterial properties. Compounds that act as antibacterial are flavonoids, saponins and allicin.The aim of this study was to prove the antibacterial activity of a single bulb garlic ethanol fraction and to find out the active compound agent which acts as an antibacterial against Staphylococcus aureus and Escherichia coli. The single bulb garlic extraction process was carried out by maceration method using 96% ethanol solvent, the extract continued with the fractionation process with ethanol, n-hexane and chloroform solvents. Antibacterial activity testing used paper disc method with a concentration of 15%, 30%, 45%, 60%, 75% and 90%, chloramphenicol positive control and aquadest negative control. Antibacterial test results the largest single bulb garlic ethanol fraction was at a concentration of 90% with a inhibition zone diameter of 8.32 in S. aureus and 9.08 in E. coli. Test the compound content using the GC-MS (Gas Chromatography-Mass Spectrometry) method. The results of the antibacterial test were the largest single garlic chloroform fraction at a concentration of 90% with an inhibition zone diameter of 8.32 in S. aureus while 9.08 in E. coli. GC-MS test results obtained organosulfur DATS compound (Dialyl trisulfide).</em></p> <p><em> </em><strong><em>Keywords</em></strong><em>: Allium Sativum L., Staphylococcus aureus, Escherichia coli, </em><em>GC-MS</em></p> AKHMAD ROKIBAN Gilang Ramadhan Riko Herdiansah Copyright (c) 2023 https://creativecommons.org/licenses/by/4.0/ 2023-12-02 2023-12-02 12 2 82 88 10.37090/jfl.v12i2.970 Hubungan Tingkat Pengetahuan Dengan Perilaku Pengobatan Acne Vulgaris Di Kalangan Pelajar Sman 4 Bandar Lampung https://jurnal.utb.ac.id/index.php/jfl/article/view/1208 <p><em>Acne vulgaris (AV) is a condition when the skin pores become clogged and cause the appearance of pus sacs on the skin causing inflammation. In general, Acne vulgaris is a teenage skin disease that most often occurs at the age of 15-18 years. The purpose of this study was to determine the relationship between the level of knowledge and acne vulgaris treatment behavior among adolescents of SMAN 4 Bandar Lampung. The type of research conducted is descriptive, analytical, cross-sectional with instruments in the form of questionnaires. The sample in this study was students of SMAN 4 Bandar Lampung. The sampling technique was carried out by random sampling with a total of 90 respondents in accordance with the inclusion criteria. Data analysis in this study used Chi-square testing techniques. The results of this study showed that the number of respondents with the female sex (74%) was more than men (26%), this result showed that women experienced acne vulgaris more often than men. and respondents experienced acne vulgaris the most at the age of 15 years (30%). The results showed the level knowledge of respondentd (54%) in yhe good category, while the level of respondent behavior (54%) in the medium category. The results of the correlation analysis test showed a relationship between the level of knoeledge and acne vulgaris treatment behavior with a significance value (p,001)&lt;0,05.</em></p> <p><em>&nbsp;</em></p> <p><em>&nbsp;</em></p> Novita Tri Wahyuni Novita Sari Eci Allesia Copyright (c) 2023 https://creativecommons.org/licenses/by-sa/4.0/ 2023-12-03 2023-12-03 12 2 89 96 10.37090/jfl.v12i2.1208 Analisis Efektivitas Biaya (Cost Effectiveness Analysis) Penggunaan Antibiotik Seftriakson Dan Sefotaksim Pada Pasien Infeksi Saluran Kemih Di Rsd Dr. A. Dadi Tjokrodipo Bandar Lampung https://jurnal.utb.ac.id/index.php/jfl/article/view/1262 <p><em>Cost-effectiveness analysis is defined as an analysis to identify, measure and compare significant costs and their consequences of alternative interventions. Antibiotics are a group of drugs most often used to treat infectious diseases. Ceftriaxone and cefotaxime are the main options for treating UTI. Urinary Tract Infection (UTI) is a disease with conditions where there are very large numbers of microorganisms in the urine and can cause infection in the urinary tract. This study was designed to analyze the cost-effectiveness of ceftriaxone and cefotaxime treatment for inpatient urinary tract infections at dr. A. Dadi Tjokrodipo. The method used is descriptive with a retrospective pharmacoeconomic analysis approach. The sampling technique was purposive sampling and sampling 92 patient. The research results show characteristics based on sex most are female as much as </em><em>55 (60%), based on age ≥56 years in 35 patients (38%), and the highest length of hospitalization was 3 days in 45 patients (49%). The most widely used profile of antibiotic drug use in patients with urinary tract infections was cefotaxime with a total of 64 patients (70%). The average cost for each type of drug therapy from ceftriaxone is 735,117 and sefotaxime is 742,178. Ceftriaxone has the highest percentage of therapeutic effectiveness at 86% compared to cefotaxime at 71%. Antibiotics that are more cost effective are ceftriaxone compared to cefotaxime with an ACER calculation of 78.455.</em></p> <p><strong><em>&nbsp;</em></strong><strong><em>Keywords</em></strong><em>: Cost Effectiveness Analysis, Urinary Tract Infections, Ceftriaxone, Cefotaxime</em></p> Lilik Koernia Wahidah Novita Tri Wahyuni Aulia Andinni Copyright (c) 2023 https://creativecommons.org/licenses/by/4.0/ 2023-12-12 2023-12-12 12 2 97 109 10.37090/jfl.v12i2.1262 Analisis Kesesuaian Dosis Obat Pada Pasien Gagal Ginjal Berdasarkan Perhitungan Klirens Kreatinin Di Rumah Sakit X https://jurnal.utb.ac.id/index.php/jfl/article/view/1097 <p><em>Patients with renal impairment have different pharmacokinetic parameters from those with normal renal function. Therefore, with kidney function that is no longer normal, administering appropriate and appropriate drugs to patients with kidney failure is important to avoid adverse drug reactions and achieve optimal drug therapy. This research aims toanalyzed drugs requiring dose adjustment in patients with kidney failure based on creatinine clearance calculations with the Cockroft Gault formula, </em><em>Chronic Kidney Disease Epidemiology Collaboration (CKD EPI) and Modification of Diet in Renal Disease (MDRD). The study was conducted using a cross-sectional method with prospective data collection by tracing data from the medical records of kidney failure patients for the period January-April 2023. Next, creatinine clearance was calculated and the dose suitability was assessed in reference to Renal Pharmacotherapy 2nd edition in 2021 and The Renal Drug Handbook 5th edition 2019. Data analysis was carried out descriptively and the Chi-Square test with SPSS to see the effect of the suitability of the dose with the formula used. The number of patients who met the inclusion criteria was 68 patients. Of the 213 drugs prescribed, 210 drugs (98.60%) were dosed correctly and 3 drugs (1.40%) were not dosed correctly. Drugs that were not properly dosed were allopurinol, ketorolac injection, and codeine. The results of the Chi-Square showed no significant difference in the suitability of the dose with the Cockroft Gault formula, Chronic Kidney Disease Epidemiology Collaboration (CKD EPI), and Modification of Diet in Renal Disease (MDRD) formulas (p = 1.000).</em></p> <p><strong><em> </em></strong><strong><em>Keywords: </em></strong><em>Renal Failure, Creatinine Clearance, Dosage Adjusment</em></p> Syifa Auliya Ilham Alifiar Citra Dewi Salasanti Copyright (c) 2023 https://creativecommons.org/licenses/by-sa/4.0/ 2023-12-21 2023-12-21 12 2 110 120 10.37090/jfl.v12i2.1097 Analisis Interaksi Obat Aktual Pada Pengobatan Pasien Gastritis Rawat Inap Di Rsud X https://jurnal.utb.ac.id/index.php/jfl/article/view/1096 <p><em>Gastritis is a health problem with a high prevalence in society. Gastritis is a digestive tract disorder that has problems with damage to the gastric mucosa. Drug interaction events occur when the effect of a drug changes due to the presence of another drug. The purpose of this study was to describe the actual incidence of drug interactions in the treatment of inpatients with gastritis at RSUD X. This research was conducted at RSUD X as an observational study with a cross-sectional study design which was carried out prospectively while the patient was undergoing treatment at the hospital during the period January-April 2023. The sample was collected using a consecutive sampling technique and a total of 64 patients who met the inclusion criteria were obtained. The research results obtained from 22 cases of potential drug interactions found actual drug interaction events in the drug combination between Potassium Chloride (KSR) and Hyoscyamine which provides a synergistic or additive pharmacodynamic interaction because it can benefit patients with increased potassium levels from the therapy. </em></p> <p><strong><em>Keywords:&nbsp; </em></strong><em>Gastritis, Aktual Drug Interaction </em></p> Nadila Oktaviani Ilham Alifiar Dichy Nuryadin Zain Copyright (c) 2023 https://creativecommons.org/licenses/by-sa/4.0/ 2023-12-21 2023-12-21 12 2 121 127 10.37090/jfl.v12i2.1096 Formulasi Sediaan Pewarna Pipi Dari Ekstrak Daun Jawer Kotok (Plectranthus scutellarioides (L.) R.Br) Dalam Bentuk Compact Powder https://jurnal.utb.ac.id/index.php/jfl/article/view/1305 <p><em>Blush on</em><em> was cosmetic used to color the cheeks so that it can improve fresh impression in makeup. Plectranthus scutellarioides (L.) R.Br has anthocyanin content could be used as a natural dye. This research aims to make a rouge from Plectranthus scutellarioides (L.) R.Br extract in the form of compact powder. To get Plectranthus scutellarioides (L.) R.Br extraction we had to macerate 3 kilogram Plectranthus scutellarioides (L.) R.Br into 96% etanol liquid then the maserate is evaporated with rotary evaporator to obtained thick extract. Further more rouge were formulated with kaolin, talc, zinc stearate, oleum rosae, isopropyl myristate, lanolin, and nipagin. Plectranthus scutellarioides (L.) R.Br extract with variations in concentration 6% (F1), 8% (F2) and 10% (F3). After that could be evaluated (color dispersion test, crack test, polishing test, irritation test, hedonic test, and stability test. The results from Plectranthus scutellarioides (L.) R.Br extract result color light brown for F1, red brown for F2 and dark red for F3.</em> <em>Based on the test result all formulation had a homogeny color, not cracked in the crack test qualify for the irritation test. Dosage formulations with concentration 10% many liked. While on the method low temperature stability all preparations no changed organoleptic (color, smell and shape) but in the test high temperature stability of all formulations the preparation has a slight discoloration at thefourth week. The color looks faded not like the beginning. It is because the content of anthocyanin contained in Plectranthus scutellarioides (L.) R.Br extract decreases. Plectranthus scutellarioides (L.) R.Br extract cannot be formulated as a rouge because does not give color in the polish test, powder is rough so the color cannot stick to the skin.</em></p> <p><em>&nbsp;</em><strong><em>Keywords</em></strong><em> : Plectranthus scutellarioides (L.) R.Br, Coleus atropurpureus (L.) Benth, rounge, formulation</em></p> Laila Susanti Subur Widodo Siti Nurjanah Sivitha Sivitha Copyright (c) 2023 https://creativecommons.org/licenses/by-sa/4.0/ 2023-12-22 2023-12-22 12 2 128 139 10.37090/jfl.v12i2.1305 Analisis Kepuasan Pasien Rawat Jalan Instalasi Farmasi di Rsud Islamic Centre Kota Agung Tanggamus Dengan Menggunakan Metode Servqual Periode https://jurnal.utb.ac.id/index.php/jfl/article/view/1339 <p>Based on the results of the study, it was found that the characteristics of female respondents were more than that of men. Based on the age of the respondents 17-65 years, the results obtained from the analysis were more than 26-35 years old, totaling 32 respondents with a percentage of 41%. Characteristics of respondents based on private employment, self-employed, civil servants, and others were obtained with the largest number, namely other jobs with a value of 54 respondents and a percentage of 69%, characteristics based on education at the level of SD, SMP, SMA, Diploma, Bachelor and others. more respondents with high school level education, amounting to 39 with a percentage of 50%. Based on the sociodemographic data of BPJS respondents and in general, there were more BPJS patients, namely 56 respondents with a percentage of 71%. Based on the results of the analysis of the reality value and the expected value of the five dimensions of servqual reliability, responsiveness, assurance, empathy and physical facilities, the average value or overall real value is 389 and the average expectation value is 391.4. The value of the service quality of the respondents from the five dimensions of servqual, namely reliability, responsiveness, assurance, empathy and physical facilities obtained an average value (-1.6), the value of the level of patient satisfaction based on the five servqual dimensions the average number was obtained (0.994), and Based on the analysis of the level of patient satisfaction with the pharmacy installation service at the Islamic Center Hospital, Kotaagung Tanggamus, the reality value is obtained from the five servqual dimensions with an average value of 389.</p> <p>Keywords: <em>Respondent Satisfaction, RSUD Kotaagung Tanggamus Islamic Centr</em><em>e</em>, <em>Servqual Dimension, Service Quality, </em>Sociodemographics of Respondents.</p> Gina Ratnasari Nopiyansyah Nopiyansyah Samsuar Samsuar Erniyati Erniyati Riko Herdiansah Copyright (c) 2023 https://creativecommons.org/licenses/by-sa/4.0/ 2023-12-30 2023-12-30 12 2 140 148 10.37090/jfl.v12i2.1339