JFL : Jurnal Farmasi Lampung

AKTIVITAS ANTIBAKTERI KOMBINASI EKSTRAK DAUN JAMBU BIJI (Psidium guajava L.)DENGAN DAUN SIRSAK ( Annona muricata L.) TERHADAP Escherichia coli

Samsuar Samsuar — 2022-12-09

Infection is a type of disease that is often found in developing countries, including Indonesia. Escherichia coli is one of the most common causes of infection in society. The most common clinical symptoms in cases of this infection include watery diarrhea, abdominal cramps, low-grade fever, nausea, and malaise. Guava plants (Psidium guajava L.) and soursop plants (Annona muricata L.) are medicinal plants that are easy to find in Indonesia. Guava leaves and soursop leaves can be used as antibacterials. This study aims to determine the antibacterial activity of a combination of guava leaf extract (Psidium guajava L.) and soursop leaves (Annona muricata L.) against Escherichia coli bacteria. The method used is an experimental method of combining the concentrations of guava leaf extract and soursop leaves, namely K1 (100% + 0%), K2 (80% + 20%), K3 (60% + 40%), K4 (50% + 50% ), K5 (40%+60%), K6 (20%+80%), K7 (0%+100%), K(-) aquadest, K(+)

Ciprofloxacin which was then followed by testing for Escherichia coli bacteria using the hole or well method. The variable measured in this study was the diameter of the inhibition zone formed in the combination of extracts. The results of observations were analyzed using One Way Annova with a sig value (0.000) <p value (0.050) followed by a follow-up tukey test which showed K1, K2, K3, K4, K5, K6, K7, K(-) and K(+) real different. It can be concluded from this study that the largest inhibition zone of combined extracts was found in K2 (80% guava leaf extract + 20% soursop leaf extract) with an average inhibition zone of 11.89 mm which belonged to the strong category. Inhibits the growth of E.coli bacteria.

Keywords : guava leaves, soursop leaves, Escherichia coli, inhibition zone

KOMBINASI EKSTRAK DAUN BIDARADENGAN DAUN KEMANGI SEBAGAI ANTIBAKTERI TERHADAP Staphylococcus aureus DAN Escherichia coli.

Muhammad Richja As seffi — 2022-12-09

Infectious diseases are still at the top of the list of causes of illness and death in developing countries including Indonesia, Staphylococcus aureus and Escherichia coli are commonly found around the human environment, therefore prevention is needed to reduce infection by utilizing plants that have antibacterial effects such as bidara leaves with basil leaves. This study aims to determine the antibacterial activity of the combination of bidara leaf extract and basil leaves, and to determine the best combination concentration in inhibiting the growth of Staphylococcus aureus and Escherichia coli bacteria compared to single extracts and positive controls. Using the diffusion method, the combination of dau bidara extract with basil leaves is K1 (0% + 100 %), K2 (20 + 80%), K3 (40% + 60%), K4 (50% + 50%), K5 (60 %+40%), K6 (80%

+ 20%), K7 (100% + 0%), K(-) Aquadest and K(+) Ampicillin. In the bacterial test (well diffusion method). The variable measured in this study was the diameter of the inhibition zone formed by the combination of extracts. Data analysis was tested using One Way Anova. The sig value for Staphylococcus aureus was 0.000≤0.05, while for Escherichia coli was 0.000≤0.05, it indicated that there was a significant difference between the test groups. The results of this study obtained the largest inhibition zone on bacteria, S. aureus, namely at K7 14.46 mm had a strong inhibitory response, while in bacteria E. Coli was found in K7 with the largest average value of 17.95 mm having a strong inhibitory response. This study can be concluded that the combination of bidara leaves and basil leaves has greater antibacterial power against Staphylococcus aureus and Escherichia coli bacteria than single extracts and positive control.

Keywords: Ampicillin, antibacterial, Bidara leaves, basil leaves, diffuse

STUDI FARMAKOVIGILAN OBAT ANTIHIPERTENSI PADA PASIEN HIPERTENSI RAWAT JALAN DI DR. A. DADI TJOKRODIPO BANDAR LAMPUNG PERIODE OKTOBER–NOVEMBER 2021

Lilik Koernia Wahidah — 2022-12-12

Hypertension, also known as high blood pressure, is systolic pressure140 and diastolic pressure 80 mmHg. The more blood pressure is pumped by the heart and the narrower the arteries, the higher the blood pressure. This study aims to determine the occurrence of adverse drug reactions in hypertensive patients in RSD DR. A. Dadi Tjokrodipo Bandar Lampung. This research is a descriptive research with total sampling method. Collecting data by looking at the patient's medical record data. The results showed that the female sex was more dominant in suffering from hypertension, namely 20 female patients (62.5%) and 12 male patients (37.5%). The highest age characteristics were found in the age range of 46-55 years as many as 14 patients (43.75%). The most characteristic of hypertension was in the case of stage 2 hypertension with a total of 17 patients (53.12%). The highest pattern of drug use was amlodipine (37.5%). The incidence of drug interactions was 10 cases (31.25%) with minor severity. The highest incidence of ADR was in the "moderately probable" 1-4 with a total of 15 cases (46.87%).

Keywords: ADR, hypertension, drug interactions, antihypertensive drugs

PENGARUH PERAN FARMASIS TERHADAP PENGETAHUAN PASIEN TENTANG PENATALAKSANAAN PENYAKIT DIARE DI PUSKESMAS RAWAT INAP SUKARAJA KOTA BANDAR LAMPUNG

Nopiyansyah Nopiyansyah — 2022-12-13

Diarrheal disease in developing countries like Indonesia is still a public health problem that can cause child death in the world. Diarrhea is a condition characterized by a person having loose stools three or more times a day. This case of diarrhea needs the role of pharmacists such as education to increase patient knowledge about the management of diarrheal diseases. Education is an activity to increase individual health knowledge regarding the management of risk factors for disease and healthy living behavior in an effort to improve public health status, prevent recurrence of disease and recover from disease. Factors that influence a knowledge that is age, education, occupation and sources of information. This study aims to determine whether there is a relationship between education and the level of patient knowledge about the management of diarrheal diseases at the Sukaraja Inpatient Health Center, Bandar Lampung City. This research is a non-experimental research with an observational analytic research design, using a one group pre-test and post-test study design that can be analyzed using the Statistical Product and Service Solutions (SPSS) method. This study was conducted for 2 months with the results of the study showing the characteristics of patients based on age, the most were 26-45 years old with 19 people (47.5%), high school education as many as 20 people (50%), and the most type of work was housewives 17 people (42.5%). The level of patient knowledge after being given an education can be seen from the Wilcoxon test with a significant value <0.005, stating that there is a relationship between education and the level of patient knowledge about the management of diarrheal diseases at the Sukaraja Inpatient Health Center, Bandar Lampung.

Keywords: Diarrhea, Education, Knowledge Level.

UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN ANTING-ANTING (Acalypha australis L.) PADA MENCIT YANG DI INDUKSI KARAGENIN 1%

Novita Sari — 2022-12-15

Inflammation is the body's defense mechanism in response to tissue injury and disturbance by external factors. Anting-anting leaf (Acalypha australis L.) contain flavonoids and tannins suspected to have antiinflammatory activity.This study aims to examine the antiinflammatory activity of Anting-anting leaf (Acalypha australis L.) ethanol extract in mice induced by carrageenin 1%. Anti-inflammatory activity test was carried out using twenty-five (25) mice and each mice was induced using 1% carrageenin subplantarly. The mice were divided into 5 groups, group I as the negative control was administered 1% Na-CMC suspension, group II as the positive control was administered mefenamic acid 65 mg/kg BW, groups III, IV and V as the treatment group were administered 83, 166 and 332 mg/kg BW of Anting-anting leaf (Acalypha australis L.) ethanol extract. Inflammation volume was measured using a caliper every 60 minutes for 6 hours. Data were analyzed statistically using ANOVA (Analysis of variance). The results showed the Anting-anting leaf (Acalypha australis L.) ethanol extract 83, 166 and 332 mg/kg BW had anti-inflammatory activity, respectively (47.39 ± 1.7), (59.53 ± 0.9) and (50.56 ± 0.3)% in mice induced by carrageenin 1%. The ANOVA test showed there was a significant difference to the negative control. Based on the results of the study, it can be concluded that the ethanol extract from Anting-anting leaf (Acalypha australis L.) ethanol extract has anti-inflammatory activity with an effective dose of 332.28 mg/kg BW.

Keywords: Anti-inflammatory, Anting-anting leaf, Acalypha australis L., carrageenin