JFL : Jurnal Farmasi Lampung

PENETAPAN NILAI SPF (SUN PROTECTION FACTOR) SEDIAAN KRIM TABIR SURYA DI KOTA BANDAR LAMPUNG DENGAN METODE SPEKTROFOTOMETRI UV-VIS

Subur Widodo — 2023-06-16

Nowadays people awareness of the healthy skin importance is increasing, this is evident by the increasing cosmetic brands and there are many beauty clinics. Cosmetic products marketed should have the same efficacy as those listed on the packaging. Therefore, determining the efficacy of sunscreen preparations is very important to see the compliance of cosmetics manufacturers. The purpose of this study was to determine the suitability of the SPF product efficacy. The samples are the products which have SPF 30, the sample was tested by in vitro method using UV-Vis spectrophotometer, every 5 nm with the wavelength range 290 nm - 320 nm absorbance was measured, then analyzed with the mansur equation. Also did antioxidant activity tested with vitamin C as a control positive using the DPPH method. The principle of the DPPH method is the measurement of absorbance of DPPH radicals which are degraded due to the presence of antioxidant compounds using a UV-Vis spectrophotometer. The decrease in DPPH absorbance intensity is proportional to the increase in the concentration of antioxidant compounds expressed in IC₅₀(Inhibition Concentration 50). Sample 4 has an SPF value close to the value written on the packaging. Samples 2, 5, 1, 3, 6, 7 and 8 have SPF values smaller than those listed on the packaging. The antioxidant activity obtained is rateable to the SPF value, sample 4 has the highest antioxidant activity followed by sample 2, sample 5, sample 1, sample 3, sample 6, and sample 7 and sample 8 have the lowest antioxidant activity.

Keywords: Antioxidant , DPPH, UV-Vis spectrophotometry, SPF, Sunscreen

HUBUNGAN PENGETAHUAN DAN PERILAKU IBU DENGAN KEJADIAN ISPA PADA BALITA DI PUSKESMAS KALIREJO KECAMATAN NEGERI KATON KABUPATEN PESAWARAN

Akhmad Rokiban — 2023-06-16

Acute Respiratory Infection (ARI) is an upper or lower respiratory tract disease, where an acute infection process that lasts for 14 days, is caused by microorganisms that attack one or more parts of the respiratory tract, from the nose to the alveoli. This study aims to determine the relationship between knowledge and behavior of mothers with the incidence of ARI in children under five at the Kalirejo Public Health Center Negeri Katon District Pesawaran Regency. This type of research is descriptive observational. This research was conducted in June. The sample in this study was 100 respondents, the sampling technique in this study was accidental sampling, in this study the validity and reliabilitas Based on the chi-square results between knowledge and maternal behavior, a value (p value = 0.020) was obtained, maternal knowledge with the incidence of ARI was obtained (p value = 0.000), maternal behavior with ARI incidence was obtained (p value = 0.041). From this study, it can be concluded that the significance value < 0.05 indicates that there is a relationship between knowledge and maternal behavior, knowledge relationship with the incidence of ARI, and behavior with the incidence of ARI.

Keywords: Incidence of ARI, Knowledge, Behavior

FRAKSI ETANOL RIMPANG KENCUR (Kaempferia Galanga L.) SEBAGAI ANTIBAKTERI TERHADAP Bacillus Subtilis dan Escherichia coli

Yuli Wahyu Tri Mulyani — 2023-06-27

Abstract

People were accustomed to use natural ingredients as traditional medicine because it was more economical and has little bit side effects compared with synthetic drugs. One of the herbs that has been widely known in the community as traditional medicine was the kencur rhizome. The kencur rhizome contains flavonoid and saponins which were antibacterial. The purpose of this study was to prove that there was the inhibition in ethanol fraction of kencur rhizome towards the growth of bacillus subtilis and Escherichia coli. The extraction process of kencur rhizome was carried out by maceration method used 70% ethanol solvent and continued with fractionation by using ethanol, n-hexane and chloroform solvents. Then, antibacterial test used diffusion method with concentrations of 25%, 50%, 75%, 100%, positive control of ciprofloxacin and negative control of aquadest. The test was continued by looking at the formation of inhibition zones around the diffusion and measured by using a calipers. The highest diameter of inhibition zone antibacterial activity of kencur rhizome at concentration 100% with a diameter of 22.00 mm in E. Coli and 20.00 mm for B. Subtilis, whereas positive control diameter inhibition zone of ciproflocaxin was 40.00 mm in E. Coli and 40.0 in B. Subtilis. The conclusion of this study was the ethanol fraction of kencur rhizome 100% concentration is the best concentration in the inhibition zone.

Keywords: Antibacterial, Bacillus Subtilis, Escherichia coli, Kencur.

AKTIVITAS ANTIBAKTERI KOMBINASI EKSTRAK DAUN KEMANGI (Ocymum x africanum L.) DENGAN DAUN PEPAYA (Carica papaya L.) TERHADAP Staphylococcus aureus

Samsuar Samsuar — 2023-06-27

Abstract

Infectious diseases are one of the diseases that have suffered by many Indonesian people for a long time. S. aureus bacteria is the cause of pyogenic infections. Basil plants (Ocymum x africanum L.) and papaya plants (Carica papaya L.) can be used as antibacterial. This study aims to determine the antibacterial activity of the combination of basil and papaya leaf extracts against S. aureus bacteria. Using the Experimental Method with a combination of extract concentrations, namely K1 (0+100%), K2 (20%+80%), K3 (40%+60%), K4 (50%+50%), K5 (60%+40% ), K6 (80%+20%), K7

(100%+0%), K(-) aquadest, K(+) Oxfloxacin, followed by a test for S. aureus bacteria using the well method. The test results were analyzed using One Way Annova. with sig value (0.000) < p-value (0.05) followed by Tukey's further test which showed the combination of concentrations showed significant differences between the test groups. From this explanation, it can be concluded that the combination of basil leaf extract and papaya leaf extract can increase the inhibition zone, the largest inhibition zone is in K4 (50% basil leaf extract + 50% papaya leaf extract) the inhibitory response that appears 19.69 mm belongs to the strong category. inhibit the growth of S. aureus bacteria.

Keywords: Antibacterial, basil leaf, papaya leaf, Staphylococcus aureus.

EVALUASI PENGGUNAAN OBAT HIPERTENSI PADA PASIEN RAWAT JALAN DI RUMAH SAKIT BHAYANGKARA POLDA LAMPUNG TAHUN 2020

Lilik Koernia Wahida — 2023-07-01

ABSTRACT

Hypertension is a condition in which a person experiences an increase in blood pressure above normal, which is higher than 140 mmHg systolic or 90 mmHg diastolic. Hypertension plays a very important role in causing the death of thousands of people, due to its dangerous side-effects, such as stroke, heart attack, heart failure, and kidney failure. The purpose of this study is to evaluate the use of hypertension drugs in outpatient hypertension patients at Bhayangkara Polda Hospital Lampung. Evaluation of drug use is a quality assurance process in the use of drugs in hospitals aimed at ensuring the drugs used are appropriate, safe and effective. The data collection technique in this study began with the selection process of outpatient medical records who had a primary diagnosis of hypertension. The population in this study were all patient medical records at the Bhayangkara Polda Lampung Hospital in the period of 2020, the use of hypertension drugs based on the right patient was 103 patients, which was 100% correct, the use of Antihypertensive drugs based on the right indication was 103 patients, which was 100% correct. the use of antihypertensive drugs based on the right drug was 82 patients with a percentage (79.61%) of the right drug and as many as 21 patients (20.39%) the wrong drug because the drug given was not in accordance with the standard used, the use of antihypertensive drug was based on the right dose as much as 103 patients were 100% on the right dose, because the dose given was in accordance with the range of antihypertensive drug therapy based on JNC VIII.

Keywords: hypertension, drug evaluation, drug use.

FORMULASI LOSION EKSTRAK DAUN SALAM (Syzygium polyanthum) SEBAGAI REPELLENT TERHADAP NYAMUK Aedes aegypti

Nopiansyah Nopiansyah — 2023-07-08

ABSTRACT

Bay leaf is part of the bay plant that contains potentially terpenoid compounds as mosquito's natural repellent. The purpose of this study was to determine the formula composition and effectiveness of repellent n-hexane bay lotion extract with concentrations of 0%, 40%, 50, and 60%. This research is an experimental research. The making of bay leaf extract is used by maceration method. Lotion is made in 4 formulas on the basis of nonionic formula namely FI with extract concentration of 0%, FII with extract concentration of 40%, FIII extract concentration of 50% and FIV with extract concentration of 60%. The results of the non-specific parameter test obtained 2.9% water content, total ash content of 5% and acid insoluble ash content of 0.6% then proceed with organoleptic test, homogeneity, pH, centrifugation, dispersion, viscosity and cycling test. Repellent activity testing is done by counting the number of mosquitoes that alight and not, the average percentage of repellent power of Aedes aegypti at a concentration of 40% is 65.3%, at a concentration of 50% that is 78.6%, and at a concentration of 60% that is 90 8%, the most effective is 60% concentration. From the results of the Anova One Way test, the value of p was 0,000 ≤ 0.05 so it was proven that there were differences in various concentrations of bay leaf extract as repellent to Aedes aegypti mosquitoes. The results of this study indicate that bay leaf extract can be made in a nonionic-based lotion lotion with various concentrations. The physical properties of lotion preparations with variations in bay leaf extract levels did not affect the physical stability of the lotion and did not change during testing and had the effectiveness of mosquito repellent.

Keywords: Aedes Aegypti, N-Hexane, Repellent, Salam Leaf Extract