PENGARUH AROMATERAPI MINYAK ATSIRI JAHE TERHADAP KADAR TRIGLISERIDA DAN KOLESTEROL DARAH TIKUS YANG DIBERI PAKAN TINGGI LEMAK
DOI:
https://doi.org/10.37090/jwputb.v1i2.41Abstract
The study aims to determine the effect of ginger (Zingiber officinale) essential oil via inhalation on blood triglyceride, total cholesterol, High Density Lipoprotein (HDL) cholesterol, and Low Density Lipoprotein (LDL) cholesterol level of rats that fed high fat diet. Eighteen albino rats (Rattus norvegicus) were devided into three treatments groups. The treatments were K1 (standard diet) as negative control, K2 (high fat diet) as positive control, and K3 (high fat diet + ginger essential oil inhalation). Blood samples were collected after 5 weeks of treatment period. The result showed the level of triglyceride, cholesterol, and HDL cholesterol at treatment K3 tend to be lower than treatment K2. LDL cholesterol level at treatment K3 show higher result than treatment K2. From the result of this study cocluded that inhalation of ginger essential oil can lowering triglyceride, total cholesterol, and LDL cholesterol level and raise HDL cholesterol level. Keywords: triglyceride, cholesterol, HDL cholesterol, LDL cholesterol, ginger essential oilReferences
Assaat, L.D. 2011. Fraksionasi senyawa aktif minyak atsiri kencur (Kaemferia galanga L.) sebagai pelangsing [disertasi]. Bogor: Fakultas Matematika dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor.
Barnett, S.A. dan M.M. Spencer. 2001. Responses of wild rats to offensive smells and tastes. Brit. J. Anim. Behav. 1:32-37.
Buchbauer, G. 1993. Biological effects of fragrances and essential oils. Journal Perfumer and flavorist. 18:19-24.
Connor, W.E. 1997. Should a low-fat, high-carbohydrate diet be recommended for everyone?. N. Engl. J. Med. 337:562-563.
Cullen, P. 2000. Evidence that triglycerides are an independent coronary heart disease risk factor. Am J Cardiol. 186(9):943-9.
Damron, W.S. 2003. Introduction to Animal Science:Biological, Industry, Perspective. New Jersey: Prentice Hall.
Daniel, M. 2000. Medical Plants Chemistry and Properties. New York: Science publisher.
Dalimartha, S. 2003. 36 Resep Tumbuhan Obat untuk Menurunkan Kolesterol. Jakarta: Penebar Swadaya.
Daryit, C.S. 2003. Coconut oil: atherogenic or not? (what therefore causes atherosclerosis?). Philip J Cardiol 31:77-104.
Fuhrman, B., M. Roseblate, T. Hayek, R. Coleman, Aviram M. 2000. Ginger extract consumption reduces plasma cholesterol, inhibits LDL oxidation and attenuates development of atherosclerosis in atherosclerotic, apolipoprotein E-Deficient mice. J. Nutr. 130: 1124-1131.
Grundy, S.M. 1991. Multifactorial etiology of hypercholesterolemia: implication for prevention coronary heart disease, ateriosclerosis and trombosis. Am.J.Cardiol. 11: 1619-1635.
Katan, M.B., M.S. Grundy, W.C. Willet. 1997. Beyond low-fat diets. N. Engl. J. Med. 337: 563-567.
Kreisberg, Robert A, Oberman A. 2003. Medical management of hyperlipidemia/ dyslipidemia. The Journal of Clinical Endocrinology and Metabolism 88(6):2445-61.
Mahendra, B. 2005. 13 Jenis Tanaman Obat Ampuh. Jakarta: Penerbit Swadaya.
Matsuoka, R., Mitsunaga T. 2011. Effects of olfactory stimulation with scent of cypress (Callitris glaucophylla) essential oil on brown adipose tissue sympathetic nerve activity of rat. Proceeding of The second symposium on Temulawak, Bogor.
Moeliandari, F., A. Wijaya. 2002. Metabolism and Anti-Atherosclerotic Mechanisms of HDL, A New Perspective. Jakarta: Prodia.
Neess GC, Zhao Z, Lopez D. 1996. Inhibitor of cholesterol biosynthesis increase hepatic low density lipoprotein degradation. Arch. Biochem. Biophys. 325:242-248.
Piliang WG, Djojosoebagyio S. 2006. Fisioligi Nutrisi Volume II. Bogor: IPB Press.
Pon V, Babu A, Liu D. 2008. Green tea cathecin and cardiovascular health: an update. Curr. Med. Chem. 15(18): 1840-1850.
Russel M. 2007. What you might not know about cholesterol [terhubung berkala]. http://cholesterol-guide-to.com [26 September 2012].
Sharma I, Gusain D, Dixit VP. 1996. Hypolipidemic and antiatherosclerotic effects of Zingiber officinale in cholesterol-fed rabbits. Phto. Res. 10:517-518.
Smith, J.B., S. Mangkoewidjojo. 1988. Pemeliharaan, Pembiakan, dan Penggunaan Hewan Percobaan di Daerah Tropis. Jakarta: UI Press.
Suckow, M.A., S.H. Weisbroth, C.L. Franklin. 2006. The Laboratory Rat. San Diego: Elsevier Academic Press.
Tanabe, M., Y.D. Chen, K. Saito dan Y. Kano. 1993. Cholesterol biosynthesis inhibitory component from Zingiber officinale Roscoe. Chem. Pharm. Bull. 41: 710-713.
