NARRATIVE REVIEW TANAMAN YANG BERPOTENSI SEBAGAI IMMUNOMODULATOR

Authors

  • Winda Trisna Wulandari Prodi S1 Farmasi, STIKes Bakti Tunas Husada Tasikmalaya
  • Gina Nur Fitria Mulyana Putri Prodi S1 Farmasi, STIKes Bakti Tunas Husada Tasikmalaya
  • Hisni Nurul Fajri Prodi S1 Farmasi, STIKes Bakti Tunas Husada Tasikmalaya
  • Indah Alvina Damayanti Prodi S1 Farmasi, STIKes Bakti Tunas Husada Tasikmalaya
  • Silvia Rahmawati Prodi S1 Farmasi, STIKes Bakti Tunas Husada Tasikmalaya
  • Dina Lestari Prodi S1 Farmasi, STIKes Bakti Tunas Husada Tasikmalaya

DOI:

https://doi.org/10.37090/jfl.v10i1.494

Abstract

COVID-19 (Coronavirus Disease-2019) is an infectious disease caused by the acute respiratory syndrome SARS-CoV-2. Currently, the COVID-19 disease outbreak is experienced by various countries around the world, including Indonesia. In overcoming it, there are several ways of deterrence that can be done, such as by increasing the body's immunity. During the COVID-19 pandemic, maintaining immunity is something that needs to be considered. In addition to vitamins, herbal plants that have the potential as immunomodulators can also be consumed. Therefore, through efforts to improve the
immune system, this review aims to obtain plants that have the potential as immunomodulators to enhance the immune system during the COVID-19 pandemic. The research method in the review used journals available online at Google Scholar with Sinta or Garuda accredited journals. The main focus of this review is herbal plants that have a role as an immunomodulator that can improve the body's immune system. The journals used are journals published in 2011-2021 with inclusion criteria, namely using Indonesian or English about plants that have the potential as immunomodulators, then the journals
obtained are analyzed. The results obtained were 30 types of plants that have potential as immune system enhancers including Dayak Onion Tubers, Papaya Leaves, Kecombrang Fruits, Pineapple Fruits, Kesambi, Soursop Leaves, Purslane, Garlic, Dates, Celery Leaves, Andaliman, Mahkota Dewa Fruit. , Moringa, Meniran, Noni Fruit, Gotu Kola, Sambiloto, Kiseureuh, Javanese Chili, Tempuyung Leaves, Basil Leaves, Ceplukan, Seaweed, Neem Leaves, Red Betel Leaf, Salam Leaves, Guava, Turmeric, Lime and Red Ginger Rhizome with compounds that act as flavonoids, alkaloids, saponins, triterpenoids,
xeronin, tannins, quersentin, -tocopherol, lycopene, catechins, diterpenoids, deoxyandrographolide, andrographolide, epicatechin isothiocyanate and curcumin.

Keywords: COVID-19, Potency of Immumodulator Plants, Flavonoids

References

DAFTAR PUSTAKA

Abbas, A., Lichtman, A., & Pillai, S. (2011). Cellular and Molecular Immunology (7th ed). Elsevier Health Sciences.

Abror, Y. K., Woelansari, E. D., & Suhariyadi, S. (2018). Immunomodulator of Ethanol Extracts of The Leaves Azadirachta indica Against Macrophage Peritoneal Cell in Mice Induced The Vaccine BCG. Jurnal Teknologi Laboratorium, 7(1), 8. https://doi.org/10.29238/teknolabjour nal.v7i1.110

Agnesa, O. S., Susilo, H., & Lestari, S. R. (2017). Aktivitas imunostimulan ekstrak bawang putih tunggal pada mencit yang diinduksi Escherichia coli. Pharmaciana, 7(1), 105. https://doi.org/10.12928/pharmaciana .v7i1.6007

Aldi, Yufri, Ogiana, N., Handayani, D., & Kunci, K. (2014). UJI IMUNOMODULATOR BEBERAPA SUBFRAKSI EKSTRAK ETIL ASETAT MENIRAN ( Phyllanthus niruri [ L ]) PADA MENCIT PUTIH JANTAN DENGAN METODA CARBON CLEARANCE. 1(1), 70–82.

Aldi, Yupri, & Dkk. (2014). Uji efek imunostimulasi ekstrak etanol herba ciplukan (pyhsalis angulata.L) terhadap aktivitas dan kapasitas fagositosis sel makrofag pada mencit putih betina. STIFI Perintis Padang Scientia, 4(1).

Alkandahri, M. Y., Subarnas, A., & Berbudi, A. (2018). Aktivitas Immunomodulator Tanaman Sambiloto (Andrographis paniculata Nees). Farmaka, 16(3), 16–20.

Aurelia. (2006). Pengaruh Pemberian Rebusan Buah Mahkota Dewa (Phaleria Macrocarpa) Terhadap Aktivitas Fagositosis Makrofag Pada Mencit Balb/C Yang Diinfeksi Salmonella Typhimurium. Semarang: Universitas Diponegoro.

Azizah, M., Wiraningsih, W., & Sari, E. R. (2017). EFEK IMUNOMODULATOR EKSTRAK ETANOL KULIT BUAH NANAS (Ananas comosus L.Merr) TERHADAP MENCIT PUTIH JANTAN DENGAN METODE BERSIHAN KARBON (Carbon Clearance). Indonesian Journal of Applied Sciences, 7(2), 2–5. https://doi.org/10.24198/ijas.v7i2.137 07

Baratawidjaja, I. R., Baratawidjaja, P. P., Darwis, A., Soo-Hwee, L., Fook- Tim, C., Bee-Wah, L., & Baratawidjaja, K. G. (1999). Prevalence of allergic sensitization to regional inhalants among allergic patients in Jakarta, Indonesia. Asian Pacific Journal of Allergy and Immunology, 17(1), 9–12.

Baratawidjaja, K., & Rengganis, I. (2012). Imunologi Dasar (10th ed). Badan Penerbit FK UI.

Bone, K., & Mills, S. (2013). Principles and Practice of Phytotherapy Modern Herbal Medicine. Elseveir.

Castro, R. I., Zarrab, & J, L. (2004). Water-soluble Seaweed Extracts Modulate the Pantoea agglomerans lipopolysaccharide (LPS). Fish Shellfish Immunol, 10, 555–558.

Chaudhary, S., Kanwar, R. K., Sehgal, A., Cahill, D. M., Barrow, C. J., Sehgal, R., & Kanwar, J. R. (2017). Progress on Azadirachta indica based biopesticides in replacing synthetic toxic pesticides. Frontiers in Plant Science, 8(May), 1–3/doi.org/10.3389/fpls.2017.00610

Christobed, A., Purnawati, R., & Susilaningsih, N. (2017). Pengaruh Pemberian Ekstrak Daun Sirih Merah (Piper Crocatum) Dosis Bertingkat Terhadap Proliferasi Limfosit Limpa Mencit Balb/C Yang Diinfeksi Salmonella Typhimurium. Jurnal Kedokteran Diponegoro, 6(2), 337– 346.

Dewi, Y. K., & Riyandari, B. A. (2020). Potensi Tanaman Lokal sebagai Tanaman Obat dalam Menghambat Penyebaran COVID-19. Jurnal Pharmascience, 7(2), 112. https://doi.org/10.20527/jps.v7i2.8793

Erniati, E., & Ezraneti, R. (2020). Aktivitas imunomodulator ekstrak rumput laut. Acta Aquatica: Aquatic Sciences Journal, 7(2), 79. https://doi.org/10.29103/aa.v7i2.2463

Etlingera, K., Terhadap, R. M. S., Malaka, M. H., Fristiohady, A., & Yusuf, M. I. (2017). Potensi Imunomodulator Ekstrak Etanol Buah Kecombrang(Etlingera Elatior (Jack) R.M.Smith) Terhadap Aktivitas Fagositosis Makrofag Mencit Jantan Galur Balb/C. Pharmacon, 6(3), 350– 355. https://doi.org/10.35799/pha.6.2017.1 7211

Fadilah, M. N. (2019). Pengaruh ekstrak jahe merah (zingiber of icinale var. Rubrum theilade) terhadap kadar tnf-α pada tikus putih jantan (rattus norvegicus strain wistar) yang diinduksi etambutol, pirazinamid, dan levofloksasin. University of Muhammadiyah Malang.

Fania Putri, Jatmiko Susilo, Richa Yuswantina, Erma Widhihastuti, F. W. (2021). Aktivitas Imunomodulator dan Kandungan Fenol Ekstrak Terpurifikasi Rimpang Jahe Merah (. 04(March), 51–59.

Firdaus, I., Perkasa, R., Fitriani, V. Y., Ibrahim, A., Farmakologi, L., Farmasi, F., & Mulawarman, U. (2016). AKTIVITAS IMUNOGLOBULIN M ( IgM ) EKSTRAK BUAH MENGKUDU ( Morinda citrifolia L .) TERHADAP TIKUS PUTIH ( Rattus Norvegiens ) PENDAHULUAN Banyak penyakitpenyakit yang disebabkan oleh terkenanya paparan mikroorganisme patogen seperti virus , bakteri dan ja. Jurnal Sains Dan Kesehatan, 1(6), 321–326.

Griana, T. P. (2019). Potential Effect of Pegagan ( Centella asiatica ( L .) Urban ) and Widuri ( Calotropis gigantea ( L .)) as Immunomodulator Potensi Tanaman Pegagan ( Centella asiatica ( L .) Urban ) dan Widuri ( Calotropis gigantea ( L .)) sebagai Imunomodulator. Journal of Food and Pharmaceutical Sciences, 7(2), 55–72.

Haeria, Dhuha, Nur Syamsi, Hasbi, I. M. (2017). UJI EFEK IMUNOMODULATOR EKSTRAK DAUN KEMANGI (Ocimum basilicum. L) DENGAN PARAMETER AKTIVITAS DAN KAPASITAS FAGOSITOSIS SEL MAKROFAG PADA MENCIT (Mus musculus) JANTAN Haeria1. 4(1), 1–5.

Hanifah, L., & Kiptiyah, K. (2020). Potensi kesambi (Scheichera oleosa) sebagai kandidat imunomodulator. Prosiding Seminar Nasional Biologi, September, 119–126.

Harun, N. H., Septama, A. W., & Jantan, I. (2015). Immunomodulatory effects of selected Malaysian plants on the CD18/11a expression and phagocytosis activities of leukocytes. Asian Pacific Journal of Tropical Biomedicine, 5(1), 48–53. https://doi.org/10.1016/S2221- 1691(15)30170-2

Hasdianah, D. P., & Peristiowati, I. S. (2014). Imunologi: Diagnosis dan Teknik Biologi Molekuler. Nuha Medika.

James, J., & Dubery, I. (2011). Identification and Quantification of Triterpenoid Centelloids in Centella asiatica (L.) Urban by Densitometric TLC. Jpc-Journal of Planar Chromatography-Modern Tlc, 24(1), 82–87. https://doi.org/10.1556/jpc.24.2011.1. 16%0D

Khan, H., Jaiswal, V., Kulshreshtha, S., & Khan, A. (2019). Potential angiotensin converting enzyme inhibitors from Moringa oleifera. Recent Pat Biotechnol, 13, 239–248.

Khumairoh, Tjandrakirana, & Budijastuti, W. (2013). Pengaruh Pemberian Filtrat Daun Sambiloto terhadap Jumlah Leukosit Darah Tikus Putih yang Terpapar Benzena. Lentera Berkala Ilmiah Biologi, 2(1), 1–5.

Koentjoro, M. P., Donastin, A., & Prasetyo, E. N. (2020). Potensi Senyawa Bioaktif Tanaman Kelor Penghambat Interaksi Angiotensin- Converting Enzyme 2 Pada Sindroma Sars-Cov-2. Jurnal Bioteknologi & Biosains Indonesia (JBBI), 7(2), 259–270. https://doi.org/10.29122/jbbi.v7i2.415 6

Kusmardi, Shirly Kumala, E. E. T. (2007). Efek Imunomodulator Ekstrak Daun Ketepeng Cina ( Cassia alata L .) terhadap Aktivitas dan Kapasitas Fagositosis Makrofag. Makara, Kesehatan, 11(2), 50–53.

Maratani. (2006). Pengaruh Pemberian Rebusan Buah Mahkota Dewa (Phaleria macrocarpa) Terhadap Produksi Reactive Oxygen Intermediate (ROI) Makrofag Pada Mencit Balb/C Yang Diinfeksi Salmonella Typhimurium. Semarang: Universitas Diponegoro.

Muchtaromah, B., Rahmi, A., & Sofiya, S. (2019). Pengaruh poliherbal ekstrak jeringau, temu mangga dan bawang putih pada fungsi hepar tikus (Rattus norwegicus). Jurnal Biology Science & Education Biologi Sel, 8(1), 71–81.

Muthia, R., & Astuti, K. I. (2018). Efek Imunomodulator Infusa Umbi Bawang Dayak (Eleutherina palmifolia L. Merr) Dengan Metode Bersihan Karbon. Jurnal Pharmascience, 5(1), 63–70. https://doi.org/10.20527/jps.v5i1.578

Nazir, E. (2020). Efek Imunostimulan Ekstrak Etanol Daun Seledri terhadap Mencit Putih Jantan. Jurnal Penelitian Farmasi Indonesia, 9(1), 1–7. https://doi.org/10.51887/jpfi.v9i1.788

Nguyen, T. T. H, W., H.J., Kang, H.K., Nguyen, V.D., Kim, Y.M., Kim, D.W., A., A., S., Xia, Y., Kim, & D. (2012). Flavonoid-mediated inhibition of SARS coronavirus 3C- like protease expressed in Pichia pastoris. Biotechnology Letters, 34(5), 831–838.

Ningsih, S., & Wibowo, A. E. (2011). Immune-Enhancing Effect of Ethanol Extract of Pegagan Herb (Centella Asiatica Urban) on Rat. Jurnal Ilmu Kefarmasian Indonesia, 9(2), 122– 125.

Nugroho, & Yun, A. (2012). Efek pemberian kombinasi buah sirih (Piper betle L) fruit, daun minaya (Plectranthus scutellarioides (L.) R. BR.) leaf, madu dan kuning telur terhadap peningkatan aktivitas dan kapasitas fagositosis sel makrofag. Media Litbang Kesehatan, 22(1), 1– 5.

Nurliyani, Wayan, T. A., & Zuheid, N. (2005). Respon Antibodi dan Aktivitas Fagositosis Makrofag Peritoneal Mencit yang Diberi Protein Susu Kuda Pasteurisasi dan Fermentasi. Media Kedokteran Hewan, 21(2), 51–57.

Omar, S., Bouziane, I., Bouslama, Z., & Djemel, A. (2020). In-Silico Identification of Potent Inhibitors of COVID-19 Main Protease (Mpro) and Angiotensin Converting Enzyme 2 (ACE2) from Natural Products: Quercetin, Hispidulin, and Cirsimaritin Exhibited Better Potential Inhibition than Hydroxy-Chloroquine Against. https://doi.org/10.26434/chemrxiv.12 181404

Osman, M. ., Adnan, A., Bakar, N. S., & Alashkham, F. (2012). The Potential Immunomodulatory Effect Of Allicin Administration In Autommune Disease Process Of Type 1 Diabetes Mellitus. International Journal of Pharmacy and Pharmaceutical Sciences, 4(5), 440–444.

Patroni, R., & Yuniarti, A. (2003). Pengaruh pemberian ekstrak etanol umbi bidara upas (Merremia mammosa) terhadap fagositosis makrofag dan produksi NO makrofag studi eksperimental Infeksi Salmonella Typhimurium pada mencit Balb/C. Semarang: Universtas Diponegoro.

Purba, S. tridelpina, & Sinaga, D. (2017). EVALUASI POTENSI EKSTRAK TUMBUHAN ANDALIMAN ( Zanthoxylum acanthopodium ) SEBAGAI POTENSI IMUNOSTIMULAN PADA TIKUS ( Rattus norvegicus L .) Sumarny Tridelpina Purba , Dian Perayanti Sinaga PENDAHULUAN Sistem imun yang baik sangat diperlukan tubuh agar dap. September, 221–227.

Putra, B., Azizah, R. N., & Nopriyanti, E. M. (2020). Efek Imunomodulator Ekstrak Etanol Herba Krokot (Portulaca oleracea L.) terhadap Tikus Putih (Rattus norvegicus) Jantan dengan Parameter Delayed Type Hypersensitivity (DTH). Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 6(1), 20– 25. https://doi.org/10.22487/j24428744.2 020.v6.i1.14106

Rahim, M. A., Suartha, I. N., & Sudimartin, L. M. (2017). Efek Imunostimulator Ekstrak Daun Kasturi (Mangifera Casturi) Pada Mencit. Indonesia Medicus Veterinus, 6(1), 10–19. https://doi.org/10.19087/imv.2017.6.1 .10

Reddy, C. (2012). No Title طرق ال عرب ية ال ل غة ت دري س . Экономика Региона, July, 32.

Rehman, Zaib Ur; Munir, M. T. (2015). Effect of garlic on the health and performance of broilers. Veterinaria, 3(1), 32–39. https://www.researchgate.net/publica tion/279959831

Rinki, S., & Mishra, R. N. (2011). Imunomodulatory Activity of Triphala Megaext. International Jurnal of Research in Pharmaceutical and Biomedical Sciences, 2(2), 579–582.

Roseno, M., Sudaryat, Y., & Widyastiwi. (2019). Aktivitas Immunomodulator Ekstrak Etanol Kemukus ( Piper cubeba ), Kiseureuh ( Piper aduncum ), dan Cabe Jawa ( Piper retrofractum ) pada Mencit Jantan Galur Balb / C. Jurnal Ilmu Kefarmasian Indonesia, 17(2), 255– 261.

Rosnizar. (2015). Uji Efek Imunostimilan Buah Kurma (Phoenix dactylifera) Pada Mencit Jantan (Mus musculus) Galur Balb/c. Prosiding Seminar Nasional Biotik, 292–297.

Santoso, T. ., Diniatik, & Kusuma, A. . (2013). EFEK IMUNOSTIMULATOR EKSTRAK ETANOL DAUN KATUK (Sauropus androgynus L Merr) TERHADAP AKTIVITAS FAGOSITOSIS MAKROFAG. Pharmacy, 10(1), 63–70. http://dx.doi.org/10.1016/j.jsames.20 11.03.003%0Ahttps://doi.org/10.1016 /j.gr.2017.08.001%0Ahttp://dx.doi.org /10.1016/j.precamres.2014.12.018% 0Ahttp://dx.doi.org/10.1016/j.precamr es.2011.08.005%0Ahttp://dx.doi.org/ 10.1080/00206814.2014.902757%0A http://dx.

Saputri, A. A. (2019). Pengaruh ekstrak jahe merah (zingiber officinale var. Rubrum theilade) terhadap kadar ifn-γ (interferongamma) tikus putih jantan strain wistar (rattus novergicus l.) Yang diinduksi dengan pirazinamid, levofloksasin dan etambutol. University of Muhammadiyah Malang.

Selvin, J., A.J., H., & A.P., L. (2004). Immunomodulatory Potential of Marine Secondary Metabolites Against Bacterial Diseases of Shrimp. Aquaculture, 230, 241– 248.

Singh, P., Hariprasad, V.R., Babu, U.V., R., M., Rao, & R.P. (2020). Potential Phytochemical Inhibitors of the Coronavirus RNA Dependent RNA Polymerase: A Molecular Docking Study. Preprint : Research Square.

Sukmayadi, A. E., Sumiwi, S. A., Barliana, M. I., & Aryanti, A. D. (2014). The Immunomodulatory Activity of Ethanol Extract of Tempuyung Leaves (Sonchus arvensis Linn.). Indonesian Journal of Pharmaceutical Science and Technology, 1(2), 65–72. https://doi.org/10.15416/ijpst.v1i2.751 5

Sulistiyani, Falah, S., Wahyuni, W. T., Sugahara, T., Tachibana, S., & Syaefudin. (2014). Cellular mechanism of the cytotoxic effect of extracts from syzygium polyanthum leaves. American Journal of Drug Discovery and Development, 4(2), 90–101. https://doi.org/10.3923/ajdd.2014.90. 101

Sumalatha, Rama Bhat, P., Ballal, S. R., & Acharya, S. (2012). Studies on immunomodulatory effects of salacia chinensis L. on albino rats. Journal of Applied Pharmaceutical Science, 2(9), 098–107. https://doi.org/10.7324/JAPS.2012.29 20

Susilawati, Y., Moektiwardoyo, M., Halimah, E., Wicaksono, I. A., Ramadhania, Z. M., & Prastiw, S. S. (2019). Aktivitas Imunomodulator Ekstrak Etanol Daun Pepaya (Carica papaya L.) dengan Metode Induksi Bakteri dan CBC-Diff. Jurnal Sains Dan Kesehatan, 2(2), 122–128.

Tallei, T. E., Tumilaar, S. G., Niode, N. J., Fatimawali, Kepel, B. J., Idroes, R., Effendi, Y., Sakib, S. A., & Emran, T. Bin. (2020). Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (Mpro) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking Study. Scientifica. https://doi.org/10.1155/2020/6307457

Tian, T., Wang, M., & Ma, D. (2014). TNF-a, a good or factor in hematogical diseases. Stem Cell Investig, 1, 12.

Tjahajati, I. (2005). VAKSINASI BCG MENINGKATKAN AKTIVITAS FAGOSITOSIS DAN SEKRESI REACTIVE OXYGEN INTERMEDIATE (ROI) PADA MAKROFAG PERITONEUM KUCING YANG DIINFEKSI DENGAN Mycobacterium tuberculosis. Jurnal Kedokteran Brawijaya, 21(2), 2–2005. https://doi.org/10.21776/ub.jkb.2005. 021.02.8

Triyani, Y., Herliani, I., Patrisia, N., Achmad, S., Hendyanny, E., & Hartati, J. (2015). Optimasi Dosis dan Perbandingan Efek Ekstrak Etanol Ceplukan (Physalis angulata) dengan Obat Herbal Imunomodulator Terstandar terhadap Aktivitas Makrofag Intraperitoneal Mencit Jantan Galur DDY. In Global Medical & Health Communication (GMHC) (Vol. 3, Issue 1, p. 25). https://doi.org/10.29313/gmhc.v3i1.1 543

Wulandari, S., Hasibuan, A. S., & Cahya, C. A. D. (2019). EFEKTIFITAS IMUNOSTIMULAN DARI EKSTRAK ETANOL DAUN SIRSAK (Annona mucirata) PADA TIKUS JANTAN DENGAN METODE HYPERSENSITIVITAS TIPE LAMBAT. Jurnal Farmasimed (Jfm), 2(1), 21–30. https://doi.org/10.35451/jfm.v2i1.304

Yatimah, D., Kustandi, C., Maulidina, A., Irnawan, F., & Andinnari, S. R. (2020). Peningkatan Kesadaran Masyarakat tentang Pencegahan COVID-19 berbasis Keluarga dengan Memanfaatkan Motion Grafis di Jakarta Timur. Jurnal Karya Abdi Masyarakat, 4(2), 246–255. https://doi.org/10.22437/jkam.v4i2.10 530

Abbas, A., Lichtman, A., & Pillai, S. (2011). Cellular and Molecular Immunology (7th ed). Elsevier Health Sciences.

Abror, Y. K., Woelansari, E. D., & Suhariyadi, S. (2018). Immunomodulator of Ethanol Extracts of The Leaves Azadirachta indica Against Macrophage Peritoneal Cell in Mice Induced The Vaccine BCG. Jurnal Teknologi Laboratorium, 7(1), 8. https://doi.org/10.29238/teknolabjour nal.v7i1.110

Agnesa, O. S., Susilo, H., & Lestari, S. R. (2017). Aktivitas imunostimulan ekstrak bawang putih tunggal pada mencit yang diinduksi Escherichia coli. Pharmaciana, 7(1), 105. https://doi.org/10.12928/pharmaciana .v7i1.6007

Aldi, Yufri, Ogiana, N., Handayani, D., & Kunci, K. (2014). UJI IMUNOMODULATOR BEBERAPA SUBFRAKSI EKSTRAK ETIL ASETAT MENIRAN ( Phyllanthus niruri [ L ]) PADA MENCIT PUTIH JANTAN DENGAN METODA CARBON CLEARANCE. 1(1), 70–82.

Aldi, Yupri, & Dkk. (2014). Uji efek imunostimulasi ekstrak etanol herba ciplukan (pyhsalis angulata.L) terhadap aktivitas dan kapasitas fagositosis sel makrofag pada mencit putih betina. STIFI Perintis Padang Scientia, 4(1).

Alkandahri, M. Y., Subarnas, A., & Berbudi, A. (2018). Aktivitas Immunomodulator Tanaman Sambiloto (Andrographis paniculata Nees). Farmaka, 16(3), 16–20.

Aurelia. (2006). Pengaruh Pemberian Rebusan Buah Mahkota Dewa (Phaleria Macrocarpa) Terhadap Aktivitas Fagositosis Makrofag Pada Mencit Balb/C Yang Diinfeksi Salmonella Typhimurium. Semarang: Universitas Diponegoro.

Azizah, M., Wiraningsih, W., & Sari, E. R. (2017). EFEK IMUNOMODULATOR EKSTRAK ETANOL KULIT BUAH NANAS (Ananas comosus L.Merr) TERHADAP MENCIT PUTIH JANTAN DENGAN METODE BERSIHAN KARBON (Carbon Clearance). Indonesian Journal of Applied Sciences, 7(2), 2–5. https://doi.org/10.24198/ijas.v7i2.137 07 72. Baratawidjaja, I. R., Baratawidjaja, P. P., Darwis, A., Soo-Hwee, L., Fook- Tim, C., Bee-Wah, L., & Baratawidjaja, K. G. (1999). Prevalence of allergic sensitization to regional inhalants among allergic patients in Jakarta, Indonesia. Asian Pacific Journal of Allergy and Immunology, 17(1), 9–12.

Baratawidjaja, K., & Rengganis, I. (2012). Imunologi Dasar (10th ed). Badan Penerbit FK UI.

Bone, K., & Mills, S. (2013). Principles and Practice of Phytotherapy Modern Herbal Medicine. Elseveir.

Castro, R. I., Zarrab, & J, L. (2004). Water-soluble Seaweed Extracts Modulate the Pantoea agglomerans lipopolysaccharide (LPS). Fish Shellfish Immunol, 10, 555–558.

Chaudhary, S., Kanwar, R. K., Sehgal, A., Cahill, D. M., Barrow, C. J., Sehgal, R., & Kanwar, J. R. (2017). Progress on Azadirachta indica based biopesticides in replacing synthetic toxic pesticides. Frontiers in Plant Science, 8(May), 1–13. https://doi.org/10.3389/fpls.2017.006 10

Christobed, A., Purnawati, R., & Susilaningsih, N. (2017). Pengaruh Pemberian Ekstrak Daun Sirih Merah (Piper Crocatum) Dosis Bertingkat Terhadap Proliferasi Limfosit Limpa Mencit Balb/C Yang Diinfeksi Salmonella Typhimurium. Jurnal Kedokteran Diponegoro, 6(2), 337– 346.

Dewi, Y. K., & Riyandari, B. A. (2020). Potensi Tanaman Lokal sebagai Tanaman Obat dalam Menghambat Penyebaran COVID- 19. Jurnal Pharmascience, 7(2), 112. https://doi.org/10.20527/jps.v7i2.879 3

Erniati, E., & Ezraneti, R. (2020). Aktivitas imunomodulator ekstrak rumput laut. Acta Aquatica: Aquatic Sciences Journal, 7(2), 79. https://doi.org/10.29103/aa.v7i2.2463

Etlingera, K., Terhadap, R. M. S., Malaka, M. H., Fristiohady, A., & Yusuf, M. I. (2017). Potensi Imunomodulator Ekstrak Etanol Buah Kecombrang(Etlingera Elatior (Jack) R.M.Smith) Terhadap Aktivitas Fagositosis Makrofag Mencit Jantan Galur Balb/C. Pharmacon, 6(3), 350– 355. https://doi.org/10.35799/pha.6.2017.1 7211

Fadilah, M. N. (2019). Pengaruh ekstrak jahe merah (zingiber of icinale var. Rubrum theilade) terhadap kadar tnf-α pada tikus putih jantan (rattus norvegicus strain wistar) yang diinduksi etambutol, pirazinamid, dan levofloksasin. University of Muhammadiyah Malang.

Fania Putri, Jatmiko Susilo, Richa Yuswantina, Erma Widhihastuti, F. W. (2021). Aktivitas Imunomodulator dan Kandungan Fenol Ekstrak Terpurifikasi Rimpang Jahe Merah (. 04(March), 51–59.

Firdaus, I., Perkasa, R., Fitriani, V. Y., Ibrahim, A., Farmakologi, L., Farmasi, F., & Mulawarman, U. (2016). AKTIVITAS IMUNOGLOBULIN M ( IgM ) EKSTRAK BUAH MENGKUDU ( Morinda citrifolia L .) TERHADAP TIKUS PUTIH ( Rattus Norvegiens ) PENDAHULUAN Banyak penyakitpenyakit yang disebabkan oleh terkenanya paparan mikroorganisme patogen seperti virus , bakteri dan ja. Jurnal Sains Dan Kesehatan, 1(6), 321–326.

Griana, T. P. (2019). Potential Effect of Pegagan ( Centella asiatica ( L .) Urban ) and Widuri ( Calotropis gigantea ( L .)) as Immunomodulator Potensi Tanaman Pegagan ( Centella asiatica ( L .) Urban ) dan Widuri ( Calotropis gigantea ( L .)) sebagai Imunomodulator. Journal of Food and Pharmaceutical Sciences, 7(2), 55–72. 85. Haeria, Dhuha, Nur Syamsi, Hasbi, I. M. (2017). UJI EFEK IMUNOMODULATOR EKSTRAK DAUN KEMANGI (Ocimum basilicum. L) DENGAN PARAMETER AKTIVITAS DAN KAPASITAS FAGOSITOSIS SEL MAKROFAG PADA MENCIT (Mus musculus) JANTAN Haeria1. 4(1), 1–5.

Hanifah, L., & Kiptiyah, K. (2020). Potensi kesambi (Scheichera oleosa) sebagai kandidat imunomodulator. Prosiding Seminar Nasional Biologi, September, 119–126.

Harun, N. H., Septama, A. W., & Jantan, I. (2015). Immunomodulatory effects of selected Malaysian plants on the CD18/11a expression and phagocytosis activities of leukocytes. Asian Pacific Journal of Tropical Biomedicine, 5(1), 48–53. https://doi.org/10.1016/S2221- 1691(15)30170-2

Hasdianah, D. P., & Peristiowati, I. S. (2014). Imunologi: Diagnosis dan Teknik Biologi Molekuler. Nuha Medika.

James, J., & Dubery, I. (2011). Identification and Quantification of Triterpenoid Centelloids in Centella asiatica (L.) Urban by Densitometric TLC. Jpc-Journal of Planar Chromatography-Modern Tlc, 24(1), 82–87. https://doi.org/10.1556/jpc.24.2011.1. 16%0D

Khan, H., Jaiswal, V., Kulshreshtha, S., & Khan, A. (2019). Potential angiotensin converting enzyme inhibitors from Moringa oleifera. Recent Pat Biotechnol, 13, 239–248.

Khumairoh, Tjandrakirana, & Budijastuti, W. (2013). Pengaruh Pemberian Filtrat Daun Sambiloto terhadap Jumlah Leukosit Darah Tikus Putih yang Terpapar Benzena. Lentera Berkala Ilmiah Biologi, 2(1), 1–5.

Koentjoro, M. P., Donastin, A., & Prasetyo, E. N. (2020). Potensi Senyawa Bioaktif Tanaman Kelor Penghambat Interaksi Angiotensin- Converting Enzyme 2 Pada Sindroma Sars-Cov-2. Jurnal Bioteknologi & Biosains Indonesia (JBBI), 7(2), 259–270. https://doi.org/10.29122/jbbi.v7i2.415 6

Kusmardi, Shirly Kumala, E. E. T. (2007). Efek Imunomodulator Ekstrak Daun Ketepeng Cina ( Cassia alata L .) terhadap Aktivitas dan Kapasitas Fagositosis Makrofag. Makara, Kesehatan, 11(2), 50–53.

Maratani. (2006). Pengaruh Pemberian Rebusan Buah Mahkota Dewa (Phaleria macrocarpa) Terhadap Produksi Reactive Oxygen Intermediate (ROI) Makrofag Pada Mencit Balb/C Yang Diinfeksi Salmonella Typhimurium. Semarang: Universitas Diponegoro.

Muchtaromah, B., Rahmi, A., & Sofiya, S. (2019). Pengaruh poliherbal ekstrak jeringau, temu mangga dan bawang putih pada fungsi hepar tikus (Rattus norwegicus). Jurnal Biology Science & Education Biologi Sel, 8(1), 71–81.

Muthia, R., & Astuti, K. I. (2018). Efek Imunomodulator Infusa Umbi Bawang Dayak (Eleutherina palmifolia L. Merr) Dengan Metode Bersihan Karbon. Jurnal Pharmascience, 5(1), 63–70. https://doi.org/10.20527/jps.v5i1.578 7

Nazir, E. (2020). Efek Imunostimulan Ekstrak Etanol Daun Seledri terhadap Mencit Putih Jantan. Jurnal Penelitian Farmasi Indonesia, 9(1), 1–7. https://doi.org/10.51887/jpfi.v9i1.788

Nguyen, T. T. H, W., H.J., Kang, H.K., Nguyen, V.D., Kim, Y.M., Kim, D.W., A., A., S., Xia, Y., Kim, & D. (2012). Flavonoid-mediated inhibition of SARS coronavirus 3C- like protease expressed in Pichia pastoris. Biotechnology Letters, 34(5), 831–838.

Ningsih, S., & Wibowo, A. E. (2011). Immune-Enhancing Effect of Ethanol Extract of Pegagan Herb (Centella Asiatica Urban) on Rat. Jurnal Ilmu Kefarmasian Indonesia, 9(2), 122– 125.

Nugroho, & Yun, A. (2012). Efek pemberian kombinasi buah sirih (Piper betle L) fruit, daun minaya (Plectranthus scutellarioides (L.) R. BR.) leaf, madu dan kuning telur terhadap peningkatan aktivitas dan kapasitas fagositosis sel makrofag. Media Litbang Kesehatan, 22(1), 1–5.

Nurliyani, Wayan, T. A., & Zuheid, N. (2005). Respon Antibodi dan Aktivitas Fagositosis Makrofag Peritoneal Mencit yang Diberi Protein Susu Kuda Pasteurisasi dan Fermentasi. Media Kedokteran Hewan, 21(2), 51–57.

Omar, S., Bouziane, I., Bouslama, Z., & Djemel, A. (2020). In-Silico Identification of Potent Inhibitors of COVID-19 Main Protease (Mpro) and Angiotensin Converting Enzyme 2 (ACE2) from Natural Products: Quercetin, Hispidulin, and Cirsimaritin Exhibited Better Potential Inhibition than Hydroxy- Chloroquine Against. https://doi.org/10.26434/chemrxiv.1 2181404

Osman, M. ., Adnan, A., Bakar, N. S., & Alashkham, F. (2012). The Potential Immunomodulatory Effect Of Allicin Administration In Autommune Disease Process Of Type 1 Diabetes Mellitus. International Journal of Pharmacy and Pharmaceutical Sciences, 4(5), 440–444.

Patroni, R., & Yuniarti, A. (2003). Pengaruh pemberian ekstrak etanol umbi bidara upas (Merremia mammosa) terhadap fagositosis makrofag dan produksi NO makrofag studi eksperimental Infeksi Salmonella Typhimurium pada mencit Balb/C. Semarang: Universtas Diponegoro.

Purba, S. tridelpina, & Sinaga, D. (2017). EVALUASI POTENSI EKSTRAK TUMBUHAN ANDALIMAN ( Zanthoxylum acanthopodium ) SEBAGAI POTENSI IMUNOSTIMULAN PADA TIKUS ( Rattus norvegicus L .) Sumarny Tridelpina Purba , Dian Perayanti Sinaga PENDAHULUAN Sistem imun yang baik sangat diperlukan tubuh agar dap. September, 221–227.

Putra, B., Azizah, R. N., & Nopriyanti, E. M. (2020). Efek Imunomodulator Ekstrak Etanol Herba Krokot (Portulaca oleracea L.) terhadap Tikus Putih (Rattus norvegicus) Jantan dengan Parameter Delayed Type Hypersensitivity (DTH). Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 6(1), 20–25. https://doi.org/10.22487/j24428744 .2020.v6.i1.14106

Rahim, M. A., Suartha, I. N., & Sudimartin, L. M. (2017). Efek Imunostimulator Ekstrak Daun Kasturi (Mangifera Casturi) Pada Mencit. Indonesia Medicus Veterinus, 6(1), 10–19. https://doi.org/10.19087/imv.2017.6 .1.10

Reddy, C. (2012). No Title طرق ال عرب ية ال ل غة ت دري س . Экономика Региона, July, 32.

Rehman, Zaib Ur; Munir, M. T. (2015). Effect of garlic on the health and performance of broilers. Veterinaria, 3(1), 32–39. https://www.researchgate.net/publi cation/279959831

Rinki, S., & Mishra, R. N. (2011). Imunomodulatory Activity of Triphala Megaext. International Jurnal of Research in Pharmaceutical and Biomedical Sciences, 2(2), 579–582.

Roseno, M., Sudaryat, Y., & Widyastiwi. (2019). Aktivitas Immunomodulator Ekstrak Etanol Kemukus ( Piper cubeba ), Kiseureuh ( Piper aduncum ), dan Cabe Jawa ( Piper retrofractum ) pada Mencit Jantan Galur Balb / C. Jurnal Ilmu Kefarmasian Indonesia, 17(2), 255–261.

Rosnizar. (2015). Uji Efek Imunostimilan Buah Kurma (Phoenix dactylifera) Pada Mencit Jantan (Mus musculus) Galur Balb/c. Prosiding Seminar Nasional Biotik, 292–297.

Santoso, T. ., Diniatik, & Kusuma, A. . (2013). EFEK IMUNOSTIMULATOR EKSTRAK ETANOL DAUN KATUK (Sauropus androgynus L Merr) TERHADAP AKTIVITAS FAGOSITOSIS MAKROFAG. Pharmacy, 10(1), 63–70. http://dx.doi.org/10.1016/j.jsames.2 011.03.003%0Ahttps://doi.org/10.1 016/j.gr.2017.08.001%0Ahttp://dx.d oi.org/10.1016/j.precamres.2014.1 2.018%0Ahttp://dx.doi.org/10.1016/ j.precamres.2011.08.005%0Ahttp:// dx.doi.org/10.1080/00206814.2014 .902757%0Ahttp://dx. 114. Saputri, A. A. (2019). Pengaruh ekstrak jahe merah (zingiber officinale var. Rubrum theilade) terhadap kadar ifn-γ (interferongamma) tikus putih jantan strain wistar (rattus novergicus l.) Yang diinduksi dengan pirazinamid, levofloksasin dan etambutol. University of Muhammadiyah Malang.

Selvin, J., A.J., H., & A.P., L. (2004). Immunomodulatory Potential of Marine Secondary Metabolites Against Bacterial Diseases of Shrimp. Aquaculture, 230, 241– 248.

Singh, P., Hariprasad, V.R., Babu, U.V., R., M., Rao, & R.P. (2020). Potential Phytochemical Inhibitors of the Coronavirus RNA Dependent RNA Polymerase: A Molecular Docking Study. Preprint : Research Square.

Sukmayadi, A. E., Sumiwi, S. A., Barliana, M. I., & Aryanti, A. D. (2014). The Immunomodulatory Activity of Ethanol Extract of Tempuyung Leaves (Sonchus arvensis Linn.). Indonesian Journal of Pharmaceutical Science and Technology, 1(2), 65–72. https://doi.org/10.15416/ijpst.v1i2.7 515

Sulistiyani, Falah, S., Wahyuni, W. T., Sugahara, T., Tachibana, S., & Syaefudin. (2014). Cellular mechanism of the cytotoxic effect of extracts from syzygium polyanthum leaves. American Journal of Drug Discovery and Development, 4(2), 90–101. https://doi.org/10.3923/ajdd.2014.9 0.101

Sumalatha, Rama Bhat, P., Ballal, S. R., & Acharya, S. (2012). Studies on immunomodulatory effects of salacia chinensis L. on albino rats. Journal of Applied Pharmaceutical Science, 2(9), 098–107. https://doi.org/10.7324/JAPS.2012. 2920

Susilawati, Y., Moektiwardoyo, M., Halimah, E., Wicaksono, I. A., Ramadhania, Z. M., & Prastiw, S. S. (2019). Aktivitas Imunomodulator Ekstrak Etanol Daun Pepaya (Carica papaya L.) dengan Metode Induksi Bakteri dan CBC-Diff. Jurnal Sains Dan Kesehatan, 2(2), 122–128.

Tallei, T. E., Tumilaar, S. G., Niode, N. J., Fatimawali, Kepel, B. J., Idroes, R., Effendi, Y., Sakib, S. A., & Emran, T. Bin. (2020). Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (Mpro) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking Study. Scientifica. https://doi.org/10.1155/2020/6307457

Tian, T., Wang, M., & Ma, D. (2014). TNF-a, a good or factor in hematogical diseases. Stem Cell Investig, 1, 12.

Tjahajati, I. (2005). VAKSINASI BCG MENINGKATKAN AKTIVITAS FAGOSITOSIS DAN SEKRESI REACTIVE OXYGEN INTERMEDIATE (ROI) PADA MAKROFAG PERITONEUM KUCING YANG DIINFEKSI DENGAN Mycobacterium tuberculosis. Jurnal Kedokteran Brawijaya, 21(2), 2–2005. https://doi.org/10.21776/ub.jkb.200 5.021.02.8

Triyani, Y., Herliani, I., Patrisia, N., Achmad, S., Hendyanny, E., & Hartati, J. (2015). Optimasi Dosis dan Perbandingan Efek Ekstrak Etanol Ceplukan (Physalis angulata) dengan Obat Herbal Imunomodulator Terstandar terhadap Aktivitas Makrofag Intraperitoneal Mencit Jantan Galur DDY. In Global Medical & Health Communication (GMHC) (Vol. 3, Issue 1, p. 25). https://doi.org/10.29313/gmhc.v3i1. 1543

Wulandari, S., Hasibuan, A. S., & Cahya, C. A. D. (2019). EFEKTIFITAS IMUNOSTIMULAN DARI EKSTRAK ETANOL DAUN SIRSAK (Annona mucirata) PADA TIKUS JANTAN DENGAN METODE HYPERSENSITIVITAS TIPE LAMBAT. Jurnal Farmasimed (Jfm), 2(1), 21–30. https://doi.org/10.35451/jfm.v2i1.30 4

Yatimah, D., Kustandi, C., Maulidina, A., Irnawan, F., & Andinnari, S. R. (2020). Peningkatan Kesadaran Masyarakat tentang Pencegahan COVID-19 berbasis Keluarga dengan Memanfaatkan Motion Grafis di Jakarta Timur. Jurnal Karya Abdi Masyarakat, 4(2), 246– 255. https://doi.org/10.22437/jkam.v4i2. 10530

Downloads

Published

2021-06-30

How to Cite

Trisna Wulandari, W. ., Nur Fitria Mulyana Putri, G. ., Nurul Fajri, H. ., Alvina Damayanti, I. ., Rahmawati, S. ., & Lestari, D. . (2021). NARRATIVE REVIEW TANAMAN YANG BERPOTENSI SEBAGAI IMMUNOMODULATOR. JFL : Jurnal Farmasi Lampung, 10(1), 25–53. https://doi.org/10.37090/jfl.v10i1.494

Most read articles by the same author(s)

Obs.: This plugin requires at least one statistics/report plugin to be enabled. If your statistics plugins provide more than one metric then please also select a main metric on the admin's site settings page and/or on the journal manager's settings pages.