UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN ANTING-ANTING (Acalypha australis L.) PADA MENCIT YANG DI INDUKSI KARAGENIN 1%

Authors

  • Novita Sari Program Studi Farmasi Universitas Tulang Bawang
  • Samsuar Samsuar Program Studi Farmasi Universitas Tulang Bawang
  • Cindi Liyana Program Studi Farmasi Universitas Tulang Bawang

DOI:

https://doi.org/10.37090/jfl.v11i2.825

Abstract

Inflammation is the body's defense mechanism in response to tissue injury and disturbance by external factors. Anting-anting leaf (Acalypha australis L.) contain flavonoids and tannins suspected to have antiinflammatory activity.This study aims to examine the antiinflammatory activity of Anting-anting leaf (Acalypha australis L.) ethanol extract  in mice induced by carrageenin 1%. Anti-inflammatory activity test was carried out using twenty-five (25) mice and each mice was induced using 1% carrageenin subplantarly. The mice were divided into 5 groups, group I as the negative control was administered 1% Na-CMC suspension, group II as the positive control was administered mefenamic acid 65 mg/kg BW, groups III, IV and V as the treatment group were administered 83, 166 and 332 mg/kg BW of Anting-anting leaf (Acalypha australis L.) ethanol extract. Inflammation volume was measured using a caliper every 60 minutes for 6 hours. Data were analyzed statistically using ANOVA (Analysis of variance). The results showed the Anting-anting leaf (Acalypha australis L.) ethanol extract 83, 166 and 332 mg/kg BW had anti-inflammatory activity, respectively (47.39 ± 1.7), (59.53 ± 0.9) and (50.56 ± 0.3)% in mice induced by carrageenin 1%. The ANOVA test showed there was a significant difference to the negative control. Based on the results of the study, it can be concluded that the ethanol extract from Anting-anting leaf (Acalypha australis L.) ethanol extract has anti-inflammatory activity with an effective dose of 332.28 mg/kg BW.

Keywords:  Anti-inflammatory, Anting-anting leaf, Acalypha australis L., carrageenin

References

Joyce, L. K.1996. Farmakologi Pendekatan Proses Keperawatan. Palembang: Buku Kedokteran Egc; (2).

Tjay, T. H., Rahardja, K. 2002. Obat-obat penting khasiat, penggunaan, dan efek-efek sampingnya. Jakarta: Elex Media Komputindo; 904 p. (5).

Ramadhani, N., Sumiwi, S. A. 2016. Aktivitas Antiinflamasi Berbagai Tanaman Diduga Berasal Dari Flavonoid. Fakultas Farmasi Universitas Padjadjaran. 14(2):111–20.

Sulaiman, B. 2017. Antidiare Effect Test Leaf Ear Extract (Acalypha indica L.) Against Mice (Mus musculus). Majalah Farmasi. 14(01):39–46.

Riansyah, Y., Lanny, M., Choesrina, R. 2015. Uji Aktivitas Antiinflamasi Ekstrak Etanol Daun Ubi Jalar Ungu (Ipomoea batatas L.) terhadap Tikus Wistar Jantan. SPeSIA Unisba. 630–6.

Direktorat Jenderal Pengawasan Obat dan Makanan. 1995. Farmakope Indonesia Edisi 4. Jakarta: Departemen Kesehatan Republik Indonesia.

Kumar, V., Abbas, A. K., Aster, J. C. Robbins basic pathology. Tenth edition. Philadelphia, Pa.: Elsevier; 2018.

Tan, H. T. Obat-obat penting khasiat, penggunaan dan efek-efek sampingnya. Edisi 6. Jakarta: Elex Media Komputindo; 2007.

Mercya,Y., Soemardji, A. A., Fanty, F. Effect of Mefenamic Acid to Acupuncture Therapy on Carrageenan-Induced Inflammatory Pain in the Hind Limb of Rat. Journal of Medicine and Health [Internet]. 2017 Feb 28 [cited 2022 Nov 3];1(5). Available from: http://journal.maranatha.edu/index.php/jmh/article/view/538

Dalimartha. 2000. Tumbuhan Obat di Sekitar Rumah Kita. Jakarta: Trubus Agriwidia.

Wijayakusuma. 1992. Tanaman Berkhasiat Obat di Indonesia. Jakarta: Pustaka Kartini.

Sosa, A., Carmelo, R. 2010. Flavonoids From Urena sinuate L. Journal of Quimica. 5(2):95-98.

Nurzaman, F., Djajadisastra, J., Elya, B. Identifikasi Kandungan Saponin dalam Ekstrak Kamboja Merah (Plumeria rubra L.) dan Daya Surfaktan dalam Sediaan Kosmetik. jki. 2018 Oct 16;85–93.

Hidjrawan, Y. 2018. "Identifikasi Senyawa Tanin Pada Daun Belimbing Wuluh (Averrhoa bilimbi L.)". p:5.

Nasrudin. Wahyono. Mustofa. Susidarti, R. A. 2017. Isolasi Senyawa Steroid Dari Kukit Akar Senggugu (Clerodendrum serratum L.). Jurnal Ilmiah Farmasi UNSRAT. 6(3):332–40.

Departemen Kesehatan Republik Indonesia. 2000. Parameter Standar Umum Ekstrak Tumbuhan Obat. Jakarta: Departemen Kesehatan Republik Indonesia.

Corsini, E., Dipaola, R., Viviani, B., Genovese, T. Lucchi, L., et al. Increased carrageenan-induced acute lung inflammation in old rats. Immunology. 2005 Juni;115(2):253–61.

Astuti, E. T. Pelatihan Penggunaan Alat Ukur Dimensi Jangka Sorong dan Mikrometer Skrup di Smk Sasmita Pamulang. 2020 ;(1):6.

Lucia, E. W. 2017. Eksperimen Farmakologik Orientasi Praklinik. Surabaya: Sandira.

Sentat, T., Handayani, F. L. 2018. "Uji Efektivitas Antiinflamasi Ekstrak etanol Tanaman Patah Tulang Terhadap Udem Telapak Kaki Mencit Yang diinduksi Karagenin". 2018;6(1):6.

Sujono, T. A., Patimah, R., Yuliani, R. 2012. Efek Antiinflamasi Infusa Rimpang Temu Putih (Curcuma zedoaria (Berg)) Pada Tikus yang diinduksi Karagenin. Fakultas Farmasi Universitas Muhammadiyah Surakarta.

Yul, H. B. Pedoman Teknologi Penanganan Pascapanen Tanaman Obat. Jakarta: Kementrian Pertanian Direktoral jenderal Hortikultura, Direktorat Budidaya dan Pascapaen Sayuran dan Tumbuhan Obat; 2011. 15-17p.

Anief, M. 1995. "Prinsip Umum dan Dasar Farmakologi". Universitas Gadjah Mada. Press, Yogyakarta. hal 57-58.

Abdurrahmat. 2014. "Luka, Peradangan dan Pemulihan, Entropi".

Zulkifli., Octaviany, E. E. 2019. "Uji Efek Analgetik Ekstrak akar Binasa Asal Kabupaten Sidenreng Rappang Terhadap Mencit dengan Metode Wring Reflex Test". vol(1).

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Published

2022-12-15

How to Cite

Sari, N. ., Samsuar, S., & Liyana, C. . (2022). UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN ANTING-ANTING (Acalypha australis L.) PADA MENCIT YANG DI INDUKSI KARAGENIN 1% . JFL : Jurnal Farmasi Lampung, 11(2), 81–90. https://doi.org/10.37090/jfl.v11i2.825

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