UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN ANTING-ANTING (Acalypha australis L.) PADA MENCIT YANG DI INDUKSI KARAGENIN 1%

Authors

  • Novita Sari Program Studi Farmasi Universitas Tulang Bawang
  • Samsuar Samsuar Program Studi Farmasi Universitas Tulang Bawang
  • Cindi Liyana Program Studi Farmasi Universitas Tulang Bawang

DOI:

https://doi.org/10.37090/jfl.v11i2.825

Abstract

Inflammation is the body's defense mechanism in response to tissue injury and disturbance by external factors. Anting-anting leaf (Acalypha australis L.) contain flavonoids and tannins suspected to have antiinflammatory activity.This study aims to examine the antiinflammatory activity of Anting-anting leaf (Acalypha australis L.) ethanol extract  in mice induced by carrageenin 1%. Anti-inflammatory activity test was carried out using twenty-five (25) mice and each mice was induced using 1% carrageenin subplantarly. The mice were divided into 5 groups, group I as the negative control was administered 1% Na-CMC suspension, group II as the positive control was administered mefenamic acid 65 mg/kg BW, groups III, IV and V as the treatment group were administered 83, 166 and 332 mg/kg BW of Anting-anting leaf (Acalypha australis L.) ethanol extract. Inflammation volume was measured using a caliper every 60 minutes for 6 hours. Data were analyzed statistically using ANOVA (Analysis of variance). The results showed the Anting-anting leaf (Acalypha australis L.) ethanol extract 83, 166 and 332 mg/kg BW had anti-inflammatory activity, respectively (47.39 ± 1.7), (59.53 ± 0.9) and (50.56 ± 0.3)% in mice induced by carrageenin 1%. The ANOVA test showed there was a significant difference to the negative control. Based on the results of the study, it can be concluded that the ethanol extract from Anting-anting leaf (Acalypha australis L.) ethanol extract has anti-inflammatory activity with an effective dose of 332.28 mg/kg BW. Keywords:  Anti-inflammatory, Anting-anting leaf, Acalypha australis L., carrageenin

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Published

2022-12-15

How to Cite

Sari, N. ., Samsuar, S., & Liyana, C. . (2022). UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN ANTING-ANTING (Acalypha australis L.) PADA MENCIT YANG DI INDUKSI KARAGENIN 1% . JFL : Jurnal Farmasi Lampung, 11(2), 81-90. https://doi.org/10.37090/jfl.v11i2.825

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