PENGARUH KONSENTRASI CARBOPOL 940 TERHADAP SIFAT FISIK GEL EKSTRAK DAUN KETUMBAR (CORIANDRUM SATIVUM L.)

EFFECT OF CARBOPOL 940 CONCENTRATION ON PHYSICAL PROPERTIES OF CORIANDER LEAF EXTRACT GEL (CORIANDRUM SATIVUM L.)

Authors

  • Davit Nugraha Program Studi D3 Farmasi, STIKes Muhammadiyah Ciamis
  • Anna Yusuf STIKes Muhammadiyah Ciamis
  • Siti Rahmah KR Program Studi D3 Farmasi, STIKes Muhammadiyah Ciamis
  • Panji Wahlanto Program Studi D3 Farmasi, STIKes Muhammadiyah Ciamis
  • Cindyvia Fawziah Program Studi D3 Farmasi, STIKes Muhammadiyah Ciamis

DOI:

https://doi.org/10.37090/jfl.v13i2.1883

Abstract

Topical gels are widely used because they are convenient to apply, easily absorbed, and have good stability. Carbopol 940 is one of the thickening agents often used in gel formulations because it can produce high viscosity at low concentrations and is compatible with various active ingredients. In gel formulation, the selection of Carbopol 940 concentration is very important to determine physical properties such as viscosity, pH, spreadability, and stability. Coriander leaves (Coriandrum sativum L.) contain bioactive compounds such as flavonoids, tannins, and saponins that have potential as antioxidants and antimicrobials. This study aims to examine the effect of Carbopol 940 concentration on the physical properties of gel containing coriander leaf extract by experimental method with variation of Carbopol 940 concentration in coriander leaf extract gel formulation. The physical properties of the gel, such as viscosity, pH, spreadability, and stability, were tested using physicochemical parameters to evaluate the effect of Carbopol concentration on the quality of the preparation. Coriander leaves (Coriandrum sativum L.) contain bioactive compounds such as flavonoids, tannins, and saponins that have potential as antioxidants and antimicrobials. The results showed that the concentration of Carbopol 940 significantly affected the physical properties of the gel, including viscosity, spreadability, and pH. The conclusion shows that the optimal formulation of Carbopol 940 can produce coriander leaf extract gel with physical properties that meet the requirements of topical drugs.

Keywords:  Gel, Coriander Leaf Extract, Formulation, Physical Properties Test

References

[1] M. Reiza Adiyasa, “Pemanfaatan obat tradisional di Indonesia: distribusi dan faktor demografis yang berpengaruh,” Jurnal Biomedika dan Kesehatan, vol. 4, no. 3, 2021, doi: 10.18051/JBiomedKes.2021.

[2] J.-N. Wei, Z.-H. Liu, Y.-P. Zhao, L.-L. Zhao, T.-K. Xue, and Q.-K. Lan, “Phytochemical and bioactive profile of Coriandrum sativum L.,” Food Chem, vol. 286, pp. 260–267, 2019, doi: https://doi.org/10.1016/j.foodchem.2019.01.171.

[3] D. Puspita Sari, R. Bellatasie, and I. Ifora, “Anti-Inflammatory Properties of Coriandrum Sativum L. : A Review,” International Research Journal of Pharmacy and Medical Sciences (IRJPMS), vol. 4, no. 2, pp. 34–38, 2021, [Online]. Available: www.theplantlist.org.

[4] B. Ahmad et al., “Assessing Phytogenic and Chemogenic Silver Nanoparticles for Antibacterial Activity and Expedited Wound Recuperation,” Nanomaterials, vol. 14, no. 3, 2024, doi: 10.3390/nano14030237.

[5] R. Meilina, E. Rosdiana, S. Rezeki, and M. Faradhiba, “Utilization of Coriander Coriandrum sativum Seeds as One of the Wound Treatment Options,” 2021. [Online]. Available: https://youtu.be/YFzj0YS79x4

[6] H. Wangensteen, A. B. Samuelsen, and K. E. Malterud, “Antioxidant activity in extracts from coriander,” Food Chem, vol. 88, no. 2, pp. 293–297, 2004, doi: https://doi.org/10.1016/j.foodchem.2004.01.047.

[7] P. Aelenei et al., “Coriander essential oil and linalool – interactions with antibiotics against Gram‐positive and Gram‐negative bacteria,” Lett Appl Microbiol, vol. 68, no. 2, pp. 156–164, Feb. 2019, doi: 10.1111/lam.13100.

[8] A. I. Foudah, M. H. Alqarni, A. Alam, M. Ayman Salkini, E. O. Ibnouf Ahmed, and H. S. Yusufoglu, “Evaluation of the composition and in vitro antimicrobial, antioxidant, and anti-inflammatory activities of Cilantro (Coriandrum sativum L. leaves) cultivated in Saudi Arabia (Al-Kharj),” Saudi J Biol Sci, vol. 28, no. 6, pp. 3461–3468, 2021, doi: https://doi.org/10.1016/j.sjbs.2021.03.011.

[9] Ajazuddin et al., “Recent expansions in an emergent novel drug delivery technology: Emulgel,” Journal of Controlled Release, vol. 171, no. 2, pp. 122–132, 2013, doi: https://doi.org/10.1016/j.jconrel.2013.06.030.

[10] E. F. Apriani, N. Kornelia, and A. Amriani, “Optimizing Gel Formulations Using Carbopol 940 and Sodium Alginate Containing Andrographis paniculata Extract for Burn-Wound Healing,” JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA, vol. 10, no. 3, pp. 300–311, Dec. 2023, doi: 10.20473/jfiki.v10i32023.300-311.

[11] J. Milutinov, V. Krstonošić, D. Ćirin, and N. Pavlović, “Emulgels: Promising Carrier Systems for Food Ingredients and Drugs,” May 01, 2023, MDPI. doi: 10.3390/polym15102302.

[12] E. Sri Sulasmi, S. Endah Indriwati, and E. Suarsini, “Preparation of Various Type of Medicinal Plants Simplicia as Material of Jamu Herbal,” 2016.

[13] A. K. Jha and N. Sit, “Extraction of bioactive compounds from plant materials using combination of various novel methods: A review,” Trends Food Sci Technol, vol. 119, pp. 579–591, 2022, doi: https://doi.org/10.1016/j.tifs.2021.11.019.

[14] B. Situmeang, W. Nuraeni, A. Malik Ibrahim, and dan Saronom Silaban, “Analysis of secondary metabolite compounds from leaves extract kesambi (Schleichera oleosa) and antioxidant activity test,” 2016. [Online]. Available: http://jurnal.unimed.ac.id/2012/index.php/jpk

[15] M. Sangi, M. R. J. Runtuwene, H. E. I. Simbala, and V. M. A. Makang, “ANALISIS FITOKIMIA TUMBUHAN OBAT DI KABUPATEN MINAHASA UTARA,” 2008.

[16] loyd V. Allen jr, Nicholas G Popovich, and Howard C. Ansel, Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems., 8th ed. Baltimore, 2005.

[17] A. N. Tavanappanavar et al., “Phytochemical analysis, GC–MS profile and determination of antibacterial, antifungal, anti-inflammatory, antioxidant activities of peel and seeds extracts (chloroform and ethyl acetate) of Tamarindus indica L,” Saudi J Biol Sci, vol. 31, no. 1, p. 103878, 2024, doi: https://doi.org/10.1016/j.sjbs.2023.103878.

[18] E. Di Giuseppe et al., “Characterization of Carbopol® hydrogel rheology for experimental tectonics and geodynamics,” Tectonophysics, vol. 642, pp. 29–45, 2015, doi: https://doi.org/10.1016/j.tecto.2014.12.005.

[19] D. Ana Rahmawati and I. Setiawan, “The Formulation and Physical Stability Test Of Gel Fruit Strawberry Extract (Fragaria x ananassa Duch.),” Journal of Nutraceuticals and Herbal Medicine, vol. 2, no. 1, 2019, [Online]. Available: http://journals.ums.ac.id/index.php/jnhm

[20] N. A. Thomas, R. Tungadi, F. Hiola, and M. S. Latif, “Pengaruh Konsentrasi Carbopol 940 Sebagai Gelling Agent Terhadap Stabilitas Fisik Sediaan Gel Lidah Buaya (Aloe Vera),” Indonesian Journal of Pharmaceutical Education, vol. 3, no. 2, Jun. 2023, doi: 10.37311/ijpe.v3i2.18050.

[21] K. T. Chow, L. W. Chan, and P. W. S. Heng, “Characterization of Spreadability of Nonaqueous Ethylcellulose Gel Matrices Using Dynamic Contact Angle,” J Pharm Sci, vol. 97, no. 8, pp. 3467–3482, Aug. 2008, doi: 10.1002/jps.21227.

[22] S. Nurman, R. Yulia, Irmayanti, E. Noor, and T. C. Sunarti, “The optimization of gel preparations using the active compounds of arabica coffee ground nanoparticles,” Sci Pharm, vol. 87, no. 4, Dec. 2019, doi: 10.3390/scipharm87040032.

[23] M. Shafiei, M. Balhoff, and N. W. Hayman, “Chemical and microstructural controls on viscoplasticity in Carbopol hydrogel,” Polymer (Guildf), vol. 139, pp. 44–51, 2018, doi: https://doi.org/10.1016/j.polymer.2018.01.080.

[24] H. Doloking, N. Tahar, Mukhriani, and Surya Ningsi, “Flavonoids: A Review On Extraction, Identification, Quantification, and Antioxidant Activity,” Ad-Dawaa’ Journal of Pharmaceutical Sciences, vol. 5, no. 1, pp. 1–26, Aug. 2022, doi: 10.24252/djps.v5i1.29329.

[25] S. Wulandari, S. M. Sinaga, and U. Harahap, “Phytochemical and FTIR Analysis Of Coriander Leaf Infusion As An Active Pharmaceutical Ingredient,” International Journal of Science, Technology & Management, vol. 4, no. 4, pp. 980–983, Jul. 2023, doi: 10.46729/ijstm.v4i4.878.

[26] A. K. Das, Md. N. Islam, Md. O. Faruk, Md. Ashaduzzaman, and R. Dungani, “Review on tannins: Extraction processes, applications and possibilities,” South African Journal of Botany, vol. 135, pp. 58–70, 2020, doi: https://doi.org/10.1016/j.sajb.2020.08.008.

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Published

2024-12-12

How to Cite

Nugraha, D., Yusuf, A., Rahmah KR, S., Wahlanto, P., & Fawziah, C. (2024). PENGARUH KONSENTRASI CARBOPOL 940 TERHADAP SIFAT FISIK GEL EKSTRAK DAUN KETUMBAR (CORIANDRUM SATIVUM L.) : EFFECT OF CARBOPOL 940 CONCENTRATION ON PHYSICAL PROPERTIES OF CORIANDER LEAF EXTRACT GEL (CORIANDRUM SATIVUM L.) . JFL : Jurnal Farmasi Lampung, 13(2). https://doi.org/10.37090/jfl.v13i2.1883

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