USING PARE FRUIT (Momordica charantia L) AS AN ANTIDEPRESSANT AGENT USING THE FORCED SWIM TEST (FST) METHOD
PARE FRUIT (Momordica charantia L) AS AN ANTIDEPRESSANT AGENT USING THE FORCED SWIM TEST (FST) METHOD
DOI:
https://doi.org/10.37090/jfl.v14i1.2419Abstrak
Depresi adalah gangguan psikologis yang ditandai dengan anhedonia, kelelahan, dan ide bunuh diri. Antidepresan sintetis sering menyebabkan efek samping yang parah dan berinteraksi dengan banyak obat, mendorong kebutuhan akan alternatif herbal. Melon pahit (Momordica charantia L.) mengandung triterpenoid, flavonoid, dan polifenol, yang memiliki potensi efek antidepresan. Penelitian ini bertujuan untuk mengevaluasi kemanjuran antidepresan ekstrak buah pare menggunakan Forced Swim Test (FST) pada tikus Balb/c jantan. Empat kelompok perlakuan ditetapkan: aquadest (kontrol), fluoxetine, stelazine, dan ekstrak pare pahit. Setelah perawatan, tikus dikenakan FST, dan waktu imobilitas dicatat. Ekstrak pare pada berat badan 2.700 mg/kg menunjukkan aktivitas antidepresan yang signifikan sebanding dengan fluoxetine (120 mg/kg).
Kata kunci: pare pahit, antidepresan, tes berenang paksa, triterpenoid, depresi
Unduhan
Referensi
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