Analisis Kesesuaian Dosis Obat Pada Pasien Gagal Ginjal Berdasarkan Perhitungan Klirens Kreatinin Di Rumah Sakit X
DOI:
https://doi.org/10.37090/jfl.v12i2.1097Abstract
Patients with renal impairment have different pharmacokinetic parameters from those with normal renal function. Therefore, with kidney function that is no longer normal, administering appropriate and appropriate drugs to patients with kidney failure is important to avoid adverse drug reactions and achieve optimal drug therapy. This research aims toanalyzed drugs requiring dose adjustment in patients with kidney failure based on creatinine clearance calculations with the Cockroft Gault formula, Chronic Kidney Disease Epidemiology Collaboration (CKD EPI) and Modification of Diet in Renal Disease (MDRD). The study was conducted using a cross-sectional method with prospective data collection by tracing data from the medical records of kidney failure patients for the period January-April 2023. Next, creatinine clearance was calculated and the dose suitability was assessed in reference to Renal Pharmacotherapy 2nd edition in 2021 and The Renal Drug Handbook 5th edition 2019. Data analysis was carried out descriptively and the Chi-Square test with SPSS to see the effect of the suitability of the dose with the formula used. The number of patients who met the inclusion criteria was 68 patients. Of the 213 drugs prescribed, 210 drugs (98.60%) were dosed correctly and 3 drugs (1.40%) were not dosed correctly. Drugs that were not properly dosed were allopurinol, ketorolac injection, and codeine. The results of the Chi-Square showed no significant difference in the suitability of the dose with the Cockroft Gault formula, Chronic Kidney Disease Epidemiology Collaboration (CKD EPI), and Modification of Diet in Renal Disease (MDRD) formulas (p = 1.000).
Keywords: Renal Failure, Creatinine Clearance, Dosage Adjusment
References
Al Amin, M., dan Juniati, D. (2017). Klasifikasi Kelompok Umur Manusia Berdasarkan Analisis Dimensi. Jurnal Ilmiah Matematika, 2(6), 1–10.
Al Kamaliah, N. I., Cahaya, N., dan Rahmah, S. (2021). Gambaran Karakteristik Pasien Gagal Ginjal Kronik Yang Menggunakan Suplemen Kalsium di Poliklinik Sub Spesialis Ginjal Hipertensi Rawat Jalan RSUD Ulin Banjarmasin. Jurnal Pharmascience, 8(1), 111. https://doi.org/10.20527/jps.v8i1.8599
Alatas, H. (2021). Penatalaksanaan Hiperurisemia Pada Penyakit Ginjal Kronik (CKD). Herb-Medicine Journal, 4(1), 1. https://doi.org/10.30595/hmj.v4i1.5805
Alvionita, Welinda Dyah Ayu, M. A. M. (2016). Pengaruh Penggunaan Asam Folat Terhadap Kadar Hemoglobin Pasien Penyakit Ginjal Kronik Yang Menjalani. J. Trop. Pharm. Chem. 2016, 3(3), 179–184.
Andriani, S., Rahmawati, F., dan Andayani, T. M. (2021). Penyesuaian Dosis Obat pada Pasien Gagal Ginjal Kronis Rawat Inap di Rumah Sakit Kabupaten Tegal, Indonesia. Majalah Farmaseutik, 17(1), 46. https://doi.org/10.22146/farmaseutik.v17i1.48683
AphA. (2012). Drug Information Handbook with International Trade Names Index (21st ed.). Lexicomp.
Ashley, C. and Dunleavy, A. (2019). The Renal Drug Handbook: The Ultimate Prescribing Guide for Renal Practitioners, 5th edition. In European Journal of Hospital Pharmacy (5th ed.). CRC Press.
Cheng, F., Li, Q., Wang, J., Wang, Z., Zeng, F., dan Zhang, Y. (2021). The effects of oral sodium bicarbonate on renal function and cardiovascular risk in patients with chronic kidney disease: A systematic review and meta-analysis. Therapeutics and Clinical Risk Management, 17, 1321–1331. https://doi.org/10.2147/TCRM.S344592
Haryati, N., Rahmawati, F., dan Wahyono, D. (2019). Penyesuaian Dosis Obat Berdasarkan Nilai Kreatinin Klirens pada Pasien Geriatri Rawat Inap di Rsup Dr. Kariadi Semarang, Indonesia. Majalah Farmaseutik, 15(2), 75. https://doi.org/10.22146/farmaseutik.v15i2.46447
Kaitang, F. Y., Moeis, E. S., dan Wongkar, M. C. P. (2019). Perbandingan Estimasi Laju Filtrasi Glomerulus Berdasarkan Formula Cockroft-Gault dengan Estimasi Laju Filtrasi Glomerulus Berdasarkan Formula Chronic Kidney Disease Epidemiology Collaboration pada Subyek Penyakit Ginjal Kronik Non-Dialisis Periode Januar. E-CliniC, 7(1), 67–70. https://doi.org/10.35790/ecl.7.1.2019.23541
KDIGO. (2021). Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Official Journal of The International Society of Nephrology, 99(3), 51–587.
Kemenkes RI. (2017). Ginjal Kronis. Http://P2ptm.Kemkes.Go.Id/.
Larry K, Golightly, Isaac Teitelbaum, Bonita A. Simendinger, Tyree H. Kiser, Gerard R. Barber, N. M. S. (2021). Renal Pharmacotherapy. In Renal Pharmacotherapy (Second). Springer Nature. https://doi.org/10.1007/978-1-4614-5800-5
Open Data Kota Tasikmalaya. (2020). Data 10 Penyakit Rawat Inap Terbanyak di RSUD dr. Soekardjo Tahun 2020. https://data.tasikmalayakota.go.id/rumah-sakit-umum-daerah-dr-soekardjo/10-besar-penyakit-rawat-inap-rsud-dr-soekardjo-tahun-2020/
Riskesdas. (2013). Riset Kesehatan Dasar 2013. Kementrian Kesehatan RI.
Roslina, A., Eka Damayanti, A., dan Thristy, I. (2022). Hubungan Tekanan Darah Dengan Kadar Ureum Dan Kreatinin Pada Pasien Diabetes Melitus Tipe 2 Di Rumah Sakit Mohammadnatsir. Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam, 12(1), 1–9. https://doi.org/10.37776/zked.v12i1.972
Rosmawanti, N., dan Kusumawardhani, G. P. (2021). Model Sistem Pakar Diagnosa Penyakit Gagal Ginjal Menggunakan Metode Teorema Bayes. Jutisi : Jurnal Ilmiah Teknik Informatika Dan Sistem Informasi, 9(3), 205. https://doi.org/10.35889/jutisi.v9i3.560
Sakata, R. K., dan Nunes, M. H. G. (2014). Analgesics use for kidney failure. Revista Dor, 15(3), 224–229. https://doi.org/10.5935/1806-0013.20140048
Sartika, F. (2022). Profile Of Creatinine Clearance In Kidney Disease Patients in dr . Doris Sylvanus Hospital Palangka Raya City. Borneo Journal of Medical Laboratory Technology (BJMLT), 4, 302–310. https://doi.org/https://doi.org/10.33084/bjmlt.v4i2.3791
Supriyanto, A. (2021). Hubungan kadar kreatinin serum dengan kualitas hidup penderita gagal ginjal kronis di RSD Balung Jember. Jurnal Ilmiah, 1, 1–10.
Tomlinson, L. A., dan Clase, C. M. (2019). Sex and the incidence and prevalence of kidney disease. Clinical Journal of the American Society of Nephrology, 14(11), 1557–1559. https://doi.org/10.2215/CJN.11030919
Tuloli, T. S., Mustapa, M. A., dan Tuli, E. P. (2017). Evaluasi Penggunaan Obat Pada Pasien Gagal Ginjal Kronik Yang Menjalani Hemodialisis Di Rsud Toto Kabila Periode 2017-2018. Parapemikir: Jurnal Ilmiah Farmasi, 8(2), 25–32.
Verdiansah. (2016). Pemeriksaan Fungsi Ginjal. 43(2), 148–154.
Veryanti, P. R., dan Meiliana, M. L. (2018). Evaluasi Kesesuaian Dosis Obat Pada Pasien Gagal Ginjal Kronik Evaluation of Drug Dose in Patients with Chronic Kidney Disease. Sainstech Farma, 11(1), 12–17.
Wicaksono, A. G., Pambudi, R. S., dan Septiana, R. (2022). Treatment Patterns of Covid-19 in Patients at Indriati Boyolali Hospital. Pancasakti Journal Of Public Health Science And Research, 2(3), 208–217. https://doi.org/10.47650/pjphsr.v2i3.563
Wijayanti, S., Sutrisna, I. (2020). Perbandingan Hasil Creatinin Clirens Test (CCT) dan Estimasi Laju Filtrasi Glomerulus (eLFG) Pada Pasien Kemoterapi di Rumah Sakit Prima Medika. Bali International1(1). http://ejournal.unbi.ac.id/index.php/BISF/article/view/130%0Ahttp://ejournal.unbi.ac.id/index.php/BISF/article/download/130/78
Yuliasari, V., Aditya, M., dan Haryanto, F. X. (2021). Penyakit Ginjal Kronis Di Komunitas Indonesia Kidney Care Club (Ikcc). 1(2), 1–8.
Zazuli, Z., Hendrayana, T., Pratiwi, B., dan Rahayu, C. (2017). Analisis Kesesuaian Dosis Pada Pasien Gangguan Fungsi Ginjal Di Suatu Rumah Sakit Pendidikan Di Kota Bandung. Acta Pharmaceutica Indonesia, 42(1), 42–49. https://doi.org/10.5614/api.v42i1.5526
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
