PENGARUH KRONOFARMAKOLOGI TERHADAP KADAR KOLESTEROL TOTAL DAN TRIGLISERIDA DALAM DARAH PASIEN PENGGUNA OBAT GOLONGAN STATIN DAN FIBRAT

Authors

  • Resna Sari Asih Program Studi Farmasi STIKes Bakti Tunas Husada
  • Ilham Alifiar Program Studi Farmasi STIKes Bakti Tunas Husada
  • Yedy Purwandy Program Studi Farmasi STIKes Bakti Tunas Husada

DOI:

https://doi.org/10.37090/jfl.v9i2.335

Abstract

ABSTRACT

Chronopharmacology is a therapy based on circadian rhythms that can be said to be relevant if the risk and symptoms of the disease are predicted to vary over time. This study aims to determine the effect of chronopharmacology on total cholesterol and triglyceride levels in the blood of patients with fibrates and statin groups, so that patients with certain diseases are encouraged to take drugs according to the organ picket hours or circadian rhythms. This study was an observational descriptive study with a cross sectional study design involving 18 patients. Primary data were obtained through interviews and checking total cholesterol and triglyceride levels while secondary data were obtained from the patient's medical record. Based on the results of the analysis using SPSS for statin drug use in the morning and at night getting a value of P = 0.003. whereas for drug use in the fibrat group in the morning and evening, P = 0.083 was obtained. Based on the results of the research that has been done, it can be concluded from 18 patients using statins and fibrates in RSUD Dr. Soekardjo Tasikmlaya, for the use of statin drugs at night is more beneficial, but in the use of fibrates in the morning or evening the same effectiveness.

Keyword : chronopharmacology, statin, fibrat

References

DAFTAR PUSTAKA

Akuyam S, Aghogho U, Aliyu, Bakari Hypertensive Northern Nigerians, Int J of Med and Med Sci. (2009). 73-74

Alsheikh-Ali AA, Abjourjaily HM, Stanek E. (2004). increases in HDL-cholesterol are the strongest predictors of risk reduction in lipid intervention trials. Circulation.110(suppl III):813

Anonim.(2018).https://zulliesikawati.wor dpress.com/2009/02/05/kronoterapidan- kronofarmakologi-untuk-obatkardiovaskuler/. [Diakses tanggal 7 Maret 2019]

Baigent, et al. (2005). Efficacy and safety of cholesterol lowering treatment: prospective meta-analysis of data from 90,056 participant in 14 randomised trials of statins. Lancet.

Cheng, T. R., Tarsia, J., Aysenne, A., Boehme, A. K., Sartor, A. E., Martin- Schild, S. (2012) Elevated Plasma Factor VIII in Patients with Ischemic Stroke: Does it have any Association with Hypertensive Heart Disease? Jounal Of Neurological Disorders & Stroke. 1027.

Desai, et al. (2014). Non-Cardiavascular effects associated with statins. British Medical Journal. 30-37 7. Krawkowski, M. and Czobor, P.(2011). Cholesterol and cognition in schizophrenia: A Double-blind study of patiesnt randomized to clozapine, olanzapine and haloperidol. 27-33

Perry, Anne G., Patricia A. potter. (2005). Buku Ajar Fundamental Keperawatan Konsep dan Praktik. Edisi 4. Jakarta: EGC

Tandra, Hans. (2018). Dari Diabetes Menuju Jantung dan Stroke. Jakarta. PT Gramedia Pustaka Utama. P30

Downloads

Published

2020-12-31

How to Cite

Sari Asih, R. ., Alifiar, I. ., & Purwandy, Y. . (2020). PENGARUH KRONOFARMAKOLOGI TERHADAP KADAR KOLESTEROL TOTAL DAN TRIGLISERIDA DALAM DARAH PASIEN PENGGUNA OBAT GOLONGAN STATIN DAN FIBRAT. JFL : Jurnal Farmasi Lampung, 9(2), 78–83. https://doi.org/10.37090/jfl.v9i2.335

Most read articles by the same author(s)

Obs.: This plugin requires at least one statistics/report plugin to be enabled. If your statistics plugins provide more than one metric then please also select a main metric on the admin's site settings page and/or on the journal manager's settings pages.